Fexofenadine is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 629   Edition : 38, Martindale    Page : 629   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Allegra,Alernex,Telfast,Afexdine,Allerfexo,Fexofenaderm,BiXin,histafree,histafree M

  ►  Strength : Tablet with 30  mg, Tablet with 60  mg, Disintegrating tablets with 30  mg, Tablet with 180  mg, Suspension with 6  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 631   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Seasonal allergic rhinitis Oral 120 mg Tablet o.d.
2 Chronic idiopathic urticaria Oral 180 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 629   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Seasonal allergic rhinitis Oral 30 mg b.d.
2 Chronic idiopathic urticaria 6 Month less than 2 Year Oral 15 mg Suspension b.d.
3 Chronic idiopathic urticaria 2Year above 2 Years Oral 30 mg Suspension b.d.

Ref :- Book : Martindale    Page : 629   Edition : 38,
►  Side Effect : Somnolence, dry mouth, headache, fatigue, Anticholinergic effects and sedation are less severe than with first-generation h1-antihistaminics, ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 775   Edition : 3,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Fexofenadine is with , , , , , , Alcohol,  Ketoconazole , Erythromycin ,
Ref :-   Book : Martindale    Page : 614,629   Edition : 38, Martindale    Page : 613,630-631   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Plasma concentrations of fexofenadine have been increased when given with erythromycin or ketoconazole, but, unlike terfenadine, licensed product information states that this was not associated with adverse effects on the QT interval. Antacids containing aluminium and magnesium hydroxide have reduced the absorption of fexofenadine. Fruit juices including grapefruit may reduce the bioavailability of fexofenadine and use together should be avoided. Sedative interactions apply to a lesser extent with the non-sedating antihistamines; they do not appear to potentiate the effects of alcohol, but it should be avoided in excess. Potentially hazardous ventricular arrhythmias have occurred when the non-sedating antihistamines astemizole and terfenadine have been given with drugs liable to interfere with their hepatic metabolism, with other potentially arrhythmogenic drugs including those that prolong the QT interval, or with those likely to cause electrolyte imbalance. Antihistamines may suppress the cutaneous histamine response to allergen extracts and should be stopped several days before skin testing. ,
Ref :-   Book : Martindale    Page : 614,629   Edition : 38,


►  Contraindication : Cardiac disease, hypokalaemia or other electrolyte imbalances, known or suspected prolongation of the QT interval,
Ref :-   Book : Martindale    Page : 613,629   Edition : 38,
  ►  Mechanism of Action :   Both neutral H 1 antagonists and inverse H 1 agonists reduce or block the actions of histamine by reversible competitive binding to the H 1 receptor. Several have been clearly shown to be inverse agonists, and it is possible that all act by this mechanism. They have negligible potency at the H 2 receptor and little at the H 3 receptor.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 277,278   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ALFALFA with Biochanin A an isoflavone found in alfalfa decrease fexofenadine level ., RED CLOVE with Biochanin A found in red clove.,chick pea inhibit OATP over P-glycoprotein in the intesine,leading to the decreased oral absorption of fexofenadine . ,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, breast milk, Renal,
    Ref :-   Book : Martindale    Page : 631   Edition : 37,


    ►    Plasma Half-life :   Min value :-   14 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 631   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 631   Edition : 37,