Fluconazole is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 580   Edition : 38   Martindale    Page : 578   Edition : 38      Page :   Edition :   

  ►   Brandname : Flumed, Forcan, Canesten Oral, Diflucan, Canesoral, Fluco-beta, Bin Li, Flucan
  ►  Strength : Tablet with 50 mg.  Tablet with 100 mg.  Tablet with 150 mg.  Tablet with 200 mg.  Suspension with 10 mg/ml.  Suspension with 40 mg/ml.  Injection with 2 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV
Reference :-   Book : Martindale    Page : 578   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Candidal balanitis Oral 150 mg Tablet Used as a single dose.
2 Blastomycosis 800 mg Given for Life-Threatening Disease; In case of Disseminated (CNS) infection; dose given daily to those patient intolerant to full course of AmB. Ref Harrison, pg 1647.
3 Pityriasis versicolor Oral 50 mg Tablet o.d. Dose given up to 6 weeks. Above dose also applies in the same way for dermatophytosis, and Candida infections of the skin.
4 Superficial candidiasis Oral 50 100 mg Tablet For superficial or mucosal candidiasis (other than genital candidiasis); Treatment usually continues for 7 to 14 days in oropharyngeal candidiasis (except in severely immunocompromised patients), for 14 days in atrophic oral candidiasis associated with dentures, and for 14 to 30 days in other mucosal candidal infections.
5 Cryptococcal meningitis Oral / i.v 400 mg Given daily as tablet or intravenous infusion; Above dose is followed by a maintenance dose of 200 to 400 mg OD. Duration of therapy is based on clinical and mycological response, but is usually at least 6 to 8 weeks.
6 Systemic candidiasis Oral / i.v 400 mg Given daily as tablet or intravenous infusion, followed by a maintenance dose of 200 to 400 mg OD. Duration of therapy is based on clinical and mycological response.
7 Acute cryptococcal meningitis in AIDS patients Oral / i.v 100 200 mg Given Daily as tablet or intravenous infusion, to prevent relapse after a primary course of antifungal treatment for acute cryptococcal meningitis in AIDS patients.
8 Immunocompromised patients at risk of fungal infections Oral / i.v 50 400 mg Given prophylactically; Daily as tablet or intravenous infusion, although long-term prophylaxis has been associated with the emergence of resistant organisms.
9 VULVOVAGINAL INFECTION Oral 150 mg Tablet Given as a single dose.
10 Candiduria 200 400 mg Given per day for 14 days. Ref Harrison, pg no. 2395.
11 Blastomycosis 400 800 mg Given for Non-Life-Threatening Disease; In case of Pulmonary or disseminated (non-CNS) disease. Dose given daily. Ref 3, pg 1647.
12 Candida Esophagitis Oral 200 mg Tablet o.d. Given above dose on the first day, followed by 100 mg daily for 7–14 days. Ref Harrison, pg 2436.

Ref :-  Book : Martindale    Page : 578   Edition : 38   Harrison's principles of internal medicine    Page : 402, 1081, 1647, 1654, 1653, 1715, 2395, 2436   Edition : 18  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Mucosal candidiasis Oral / i.v 3 6 mg/kg
2 Systemic candidiasis Oral / i.v 6 12 mg/kg o.d.
3 Prevention of fungal infections Oral / i.v 3 12 mg/kg o.d.

Ref :- Book : Martindale    Page : 579   Edition : 38  
Precaution :- If a Patient is using 'Fluconazole' drug in acute kidney injury disease, then Please dose modification   if he ever suffered from Aspergillosis disease.
►  Side Effect : Nausea, Headache, Skin rashes, Vomiting, Abdominal pain, Diarrhea, Reversible alopecia, Death, Hepatic failure, Stevens-Johnson syndrome
Ref :-   Book : Goodman    Page : 1579,1580   Edition : 37.  

►  Drug Interaction : Drug interaction of Fluconazole is with oral contraceptives, sulfonylurea hypoglycaemics, , ,  Zidovudine, Warfarin , Triazolam , Rifampicin , Astemizole, Cisapride , Bosentan , Cyclosporine , Midazolam , Nevirapine, Amitriptyline , Nortriptyline , Phenytoin , Rifabutin , Nateglinide , Terfenadine, Theophylline , Celecoxib , Tacrolimus
Ref :-   Book : Martindale    Page : 580   Edition : 38.   Martindale    Page : 580   Edition : 3.  

  ►    Mechanism of Drug Drug Interaction :  In general, fewer interactions are considered to occur with fluconazole than with either itraconazole or ketoconazole. Use of rifampicin with fluconazole results in reduced plasma concentrations of fluconazole. Fluconazole may interfere with the metabolism of some other drugs, mainly through inhibition of the cytochrome P450 isoenzymes CYP3A4 and CYP2C9. This may account for the reported increases in plasma concentrations of bosentan, ciclosporin, midazolam, nevirapine, amitriptyline, nortriptyline, phenytoin, rifabutin, sulfonylurea hypoglycaemics and nateglinide, selective cyclo-oxygenase-2-inhibitors such as celecoxib and parecoxib, tacrolimus, triazolam, warfarin, and zidovudine; fluconazole may inhibit the formation of a toxic metabolite of sulfamethoxazole. Increases in terfenadine concentrations following high doses of fluconazole have been associated with ECG abnormalities. A similar effect may be anticipated with astemizole. Use of fluconazole with cisapride could result in increased cisapride concentrations and associated toxicity. The use of fluconazole with astemizole, cisapride, or terfenadine should therefore be avoided because of the risk of cardiac arrhythmias. Syncope attributed to increased amitriptyline concentrations has occurred when amitriptyline was given with fluconazole. Fluconazole may also reduce the clearance of theophylline. The concentration of contraceptive steroids has been reported to be both increased and decreased in patients receiving fluconazole and the efficacy of oral contraceptives may be affected.
Ref :-   Book : Martindale    Page : 580   Edition : 38.  

►  Contraindication : Co-administration with dofetilide, oral midazolam, pimozide, levacetylmethadol, quinidine, lovastatin, simvastatin, or triazolam, Co-administration with ergot alkaloids metabolized by P450 3A4, such as dihydroergotamine, ergotamine, ergonovine, and methylergonovine, Pregnancy, Hypersensitivity towards it
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 627   Edition : 3.  
  ►  Mechanism of Action :   At concentrations achieved following systemic administration, the major effect of imidazoles and triazoles on fungi is inhibition of 14-a-sterol demethylase, a microsomal CYP. Imidazoles and triazoles thus impair the biosynthesis of ergosterol for the cytoplasmic membrane and lead to the accumulation of 14-a-methylsterols. These methylsterols may disrupt the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems, thus inhibiting growth of the fungi.
Ref :-   Book : Goodman    Page : 1576   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 579   Edition : 37.  

►    Plasma Half-life :   Min value :-   30 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 579   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours.  
Ref :-   Book : Martindale    Page : 579   Edition : 37.