Flucytosine is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 581   Edition : 38,

  ►   Brandname : Ancotil,Ancobon

  ►  Strength : Capsule with 250  mg, Capsule with 500  mg, Tablet with   , Oral Suspension with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12, Martindale    Page : 582   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, Topical,
Reference :-   Book : Martindale    Page : 581   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hematogenous Candida endophthalmitis 25 mg/kg q.i.d. In case of lesions that are expanding or that threaten the macula, flucytosine is combined with an IV polyene.
2 Cryptococcal meningoencephalitis 100 mg/kg Given to patient without a concomitant immunosuppressive condition; along with AmB 0.5-1 mg/kg, both drug are given daily for 6-10 weeks.
3 Cryptococcosis in HIV infected patients 100 mg/kg/day Given to patients (Pulmonary and extrapulmonary cryptococcosis without evidence of CNS involvement) who have more extensive disease, flucytosine may be added in the above doses to the fluconazole regimen for 10 weeks, with lifelong fluconazole maintenance therapy thereafter. Pulmonary and extrapulmonary cryptococcosis without evidence of CNS involvement can be treated with fluconazole (200–400 mg/d) alone. For HIV-infected patients with evidence of CNS involvement; An acceptable regimen is AmB (0.7–1 mg/kg) plus flucytosine (100 mg/kg) daily for 2 weeks followed by fluconazole (400 mg/d) for at least 10 weeks and then by lifelong maintenance therapy with fluconazole (200 mg/d).
4 Cryptococcal meningitis Dosing In Obesity: Use Ideal Body weight (Ideal BW). Example: Cryptococcal meningitis, give 25 mg/kg of Ideal BW po every 6 hr. Ref The Sanford Guide To Antimicrobial Therapy, pg 231,232 ed. 47th.

Ref :-  Book : Harrison's principles of internal medicine    Page : 1650, 1654    Edition : 18,    Page :    Edition : ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Systemic fungal infections Oral / i.v 50 mg/kg Oral Suspension b.d.
2 Systemic fungal infections From 1 Month Oral / i.v 25 37.5 mg/kg Oral Suspension

Ref :- Book : Martindale    Page : 581   Edition : 38,
►  Side Effect : rash, nausea, vomiting, diarrhea, severe enterocolitis, depress the bone marrow, leucopenia, thrombocytopenia,
Ref :-   Book : Goodman    Page : 1575   Edition : 12,

►  Drug Interaction : Drug interaction of Flucytosine is with Cytosine arabinoside (Cytarabine), Amphotericin B ,
Ref :-   Book : Martindale    Page : 581   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Cytarabine has been claimed to reduce blood concentrations of flucytosine and to antagonise its antifungal activity, although the evidence is limited. Amphotericin B can cause a deterioration in renal function, which can result in raised flucytosine blood concentrations and increased toxicity. However, the two drugs are generally regarded as having synergistic antifungal activity.,
Ref :-   Book : Martindale    Page : 581   Edition : 38,


►  Contraindication : Pregnancy,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 626   Edition : 3,
  ►  Mechanism of Action :   Flucytosine is taken up by fungal cells via the enzyme cytosine permease. It is converted intracellularly first to 5-FU and then to 5-fluorodeoxyuridine monophosphate (FdUMP) and fluorouridine triphosphate (FUTP), which inhibit DNA and RNA synthesis, respectively.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 852   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Fecal,
Ref :-   Book : Martindale    Page : 582   Edition : 38,


►    Plasma Half-life :
  Min value :-   2.5 hours,    Max value :-   6 hours,
Ref :-   Book : Martindale    Page : 581   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 581   Edition : 38,