Fludrocortisone is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 1635   Edition : 38  

  ►   Brandname : Florinef, Floricot, Astonin H
  ►  Strength : Tablet with 0.1 mg.  Ear Drop with .  Eye ointment with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 712   Edition : 12   Martindale    Page : 1634   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical
Reference :-   Book : Martindale    Page : 1668   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Primary adrenocortical insufficiency Oral 50 300 micrograms Tablet It is given daily to provide mineralocorticoid replacement in primary adrenocortical insufficiency, with glucocorticoids.
2 Salt-losing form of congenital adrenal hyperplasia Oral up to 200 micrograms Tablet Given with glucocorticoid therapy in daily doses.
3 Various inflammatory disorders Topical 0.1 % Used for its glucocorticoid actions in the treatment of various disorders in the form of eye ointment or ear drops. It has also been included in topical preparations used for skin disorders.

Ref :-  Book : Martindale    Page : 1634   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Adrenocortical insufficiency Oral 0.05 0.2 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1928   Edition : 19  
►  Side Effect : Oedema, Menstrual irregularities, Impaired wound healing, Rashes, Myopathy, Hyperglycemia, Hypertension, Hypokalemia, Heart failure, Thrombophlebitis, Secondary hypocortisolism, Increased intracranial pressure
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 504   Edition : 3.  

►  Drug Interaction : Drug interaction of Fludrocortisone is with Potassium-depleting diuretics, Thiazide Diuretics , Xanthines, Beta 2 Agonist, Anticoagulant , Salicylates, anticholinesterases, NONSTEROIDAL ANTI-INFLAMMATORY DRUGS,  Mifepristone , Furosemide , Amphotericin B
Ref :-   Book : Martindale    Page : 1632   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Use of corticosteroids with potassium-depleting diuretics, such as thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalaemia with concurrent amphotericin B or bronchodilator therapy with xanthines or beta2 agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when corticosteroids are given with NSAIDs. Response to anticoagulants may be altered by corticosteroids and requirements of antidiabetic drugs and antihypertensives may be increased. Corticosteroids may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravis. The antiglucocorticoid effect of mifepristone will antagonise the effects of corticosteroids.
Ref :-   Book : Martindale    Page : 1619,1635   Edition : 38.  

►  Contraindication : Systemic fungal infection
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 504   Edition : 3.  
  ►  Mechanism of Action :   In addition to their effects on lymphocyte number, corticosteroids profoundly alter the immune responses of lymphocytes. These effects are an important facet of the anti-inflammatory and immunosuppressive actions of the glucocorticoids. Multiple mechanisms are involved in the suppression of inflammation by glucocorticoids. Glucocorticoids inhibit the production by multiple cells of factors that are critical in generating the inflammatory response. As a result, there is decreased release of vasoactive and chemoattractive factors, diminished secretion of lipolytic and proteolytic enzymes, decreased extravasation of leukocytes to areas of injury, and ultimately, decreased fibrosis. Glucocorticoids can also reduce expression of pro-inflammatory cytokines, as well as COX-2 and NOS2. The net effect of these actions on various cell types is to diminish markedly the inflammatory response. Stresses such as injury, infection, and disease result in the increased production of cytokines, a network of signaling molecules that integrate actions of macrophages/monocytes, T lymphocytes, and B lymphocytes in mounting immune responses. Among these cytokines, interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF-) stimulate the HPA axis, with IL-1 having the broadest range of actions. IL-1 stimulates the release of CRH by hypothalamic neurons, interacts directly with the pituitary to increase the release of ACTH, and may directly stimulate the adrenal gland to produce glucocorticoids. The increased production of glucocorticoids, in turn, profoundly inhibits the immune system at multiple sites. Factors that are inhibited include components of the cytokine network, including interferon (IFN-), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukins (IL-1, IL-2, IL-3, IL-6, IL-8, and IL-12), and TNF-. Thus, the HPA axis and the immune system are capable of bidirectional interactions in response to stress, and these interactions appear to be important for homeostasis.
Ref :-   Book : Goodman    Page : 1221,1222   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway.   Garlic with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Allicin is reduces the recurrence of vaginal yeast infection --- (duke, j. (2002). handbook of medicinal herbs (2nd ed.). united stata of america: crc )
  • withanine hanve antiinflammatory effect --- (Kokate, C. & Purohit, A. (2013). Pharmacognosy. Nirali prakashan: Chennai. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .
  • https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PP5&lpg=PP5&dq=duke .
  • +j.+%282002%29.+handbook+of+medicinal+herbs+%282nd+ed.%29.+united+states+of+america:+crc+press.&source=bl&ots=iMxNGW--4H&sig=qvOrL9t7aGNOPO5wGw7_WFJ8Rjw&hl=en&sa=X&ved=0ahUKEwik4PyIpKzOAhXH0xoKHUetAogQ6AEIODAE#v=onepage&q=duke%2C%20j.%20%282002%29.%20handbook%20of%20medicinal%20herbs%20%282nd%20ed.%29.%20united%20states%20of%20america%3A%20crc%20press.&f=false .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA