Flumazenil is a Medicine belongs to BENZODIAZEPINE ANTAGONIST group whose information about Brand can be referenced from   Book : Martindale    Page : 1587   Edition : 37  

  ►   Brandname : Anexate, Romazicon
  ►  Strength : Injection with 0.1 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 1552   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Reversal of benzodiazepine-induced sedation IV 200 micrograms Injection This is followed at intervals of 60 seconds by further doses of 100 to 200 micrograms if required, to a maximum total dose of 1 mg or occasionally 2 mg (usual range, 0.3 to 1 mg); each dose should be given over 15 seconds, and further doses should only be given if an adequate response has not occurred 45 seconds after completion of the injection. If drowsiness recurs an intravenous infusion may be used, at a rate of 100 to 400 micrograms/hour.
2 Management of benzodiazepine overdose IV 200 micrograms Injection Given over 30 seconds. A further dose of 300 micrograms can be given after another 30 seconds and can be followed by doses of 500 micrograms at one-minute intervals if required, to a total dose of 3 mg or occasionally 5 mg. If a dose of up to 5 mg produces no response then further doses are unlikely to be effective. If symptoms of intoxication recur, repeated doses may be given at 20-minute intervals; not more than 1 mg, in boluses of 500 micrograms and above, should be given at any one time and not more than 3 mg in one hour. If signs of overstimulation occur during the use of flumazenil, then diazepam or midazolam may be given by slow intravenous injection.

Ref :-  Book : Martindale    Page : 1551   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Reversal of benzodiazepine-induced sedation 1 Year 17 Year IV 10 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1552   Edition : 38  
Precaution :- If a Patient is using 'Flumazenil' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Use with caution .

►  Side Effect : Dizziness, Blurred Vision, Agitation, Diaphoresis, Seizures, Cardiac arrhythmias
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 183   Edition : 3.  

►  Drug Interaction : Drug interaction of Flumazenil is with NA

  ►    Mechanism of Drug Drug Interaction : 
Ref :-   Book :    Page :    Edition : .  

►  Contraindication : In patients who are receiving benzodiazepines to control potentially life-threatening conditions, Should not be given to epileptic patients who have been receiving benzodiazepines for a prolonged period to control seizures, Use after cardiac arrest is contraindicated, It should not be used in the presence of severe intoxication with tricyclic and related antidepressants as convulsions, arrhythmias and cardiac arrest can occur, Should not be given to patients who have received neuromuscular blockers until the effects of neuromuscular blockade have fully cleared
Ref :-   Book : Martindale    Page : 1552   Edition : 38.  
  ►  Mechanism of Action :   Flumazenil is a specific benzodiazepine antagonist that binds competitively at CNS benzodiazepine receptors, reversing the centrally mediated effects of benzodiazepines.
Ref :-   Book : Martindale    Page : 1552   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 1586   Edition : 37.  

►    Plasma Half-life :   Min value :-   40 min,    Max value :-   80 min.  
Ref :-   Book : Martindale    Page : 1552   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA