Flunarizine is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book :    Page :   Edition : , Martindale    Page : 630   Edition : 38,

  ►   Brandname : Zinepra,Cinzin, Fine, Fu Rui Er, Flunavert

  ►  Strength : with   ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 629   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral Flunarizine hydrochloride is used for migraine prophylaxis, for vertigo and vestibular disorders, and for peripheral and cerebral vascular disorders. The usual dose is 5 to 10 mg daily, usually given at night to minimise the effects of drowsiness.

Ref :-  Book : Martindale    Page : 629   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : weight gain, extrapyramidal symptoms, ,
Ref :-   Book : Martindale    Page : 630   Edition : 38,

►  Drug Interaction : Drug interaction of Flunarizine is with Alcohol, Barbiturates , Hypnotics, Opoid analgesic , Anxiolytic sedatives, Antipsychotics, Tricyclic antidepressants, Monoamine Oxidase Inhibitors, Aminoglycoside antibiotic ,  Carbamazapine , Phenytoin , Valproic acid(sodium valproate), Atropine ,
Ref :-   Book : Martindale    Page : 614,630   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Hepatic enzyme inducers such as carbamazepine, phenytoin, and valproate may interact with flunarizine by increasing its metabolism; an increase in dosage of flunarizine may be required. Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). It has been suggested that some sedating antihistamines could mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibiotics. Antihistamines may suppress the cutaneous histamine response to allergen extracts and should be stopped several days before skin testing.,
Ref :-   Book : Martindale    Page : 614,630   Edition : 38,


►  Contraindication : those affected should not drive or operate machinery, alcohol administration, neonates, Inappropriate use for postural giddiness in Elderly patients, young children, topical antihistamines should not be used on broken or eczematous skin ,
Ref :-   Book : Martindale    Page : 613,630   Edition : 38,
  ►  Mechanism of Action :   Flunarizine is the difluorinated derivative of cinnarizine. It has antihistamine, sedative, and calcium-channel blocking activity.,
Ref :-   Book : Martindale    Page : 629   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary,
Ref :-   Book : Martindale    Page : 630   Edition : 38,


►    Plasma Half-life :
  Min value :-   elimination half-life of about 18 days,    Max value :-   NA
Ref :-   Book : Martindale    Page : 630   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   2 to 4 hours ,    Max value :-   NA
Ref :-   Book : Martindale    Page : 630   Edition : 38,