Flunisolide is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 1670   Edition : 37,

  ►   Brandname : Syntaris,AeroBid,AeroSpan

  ►  Strength : Aerosol with 80  mcg/puff, Aerosol with 250  mcg/puff,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 355   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation, intranasal,
Reference :-   Book : Martindale    Page : 1670   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis and treatment of allergic rhinitis Local 29 micrograms Nasal Spray b.d. The starting dose is 2 sprays into each nostril, increased if necessary to three times daily, and then reduced for maintenance (each metered spray contains 29 micrograms flunisolide hemihydrate). A maximum dose of 8 sprays into each nostril daily has been established.
2 Asthma inhalation 500 micrograms metered-dose aerosol b.d. In severe asthma the dosage may be increased but should not exceed a total of 2 mg daily.

Ref :-  Book : Martindale    Page : 1635   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Prophylaxis and treatment of allergic rhinitis 6 Year 14 Year Topical 29 micrograms Nasal Spray b.d.
2 Asthma 6 Year 15 Year inhalation 500 micrograms metered-dose aerosol b.d.

Ref :- Book : Martindale    Page : 1635   Edition : 38,
►  Side Effect : oropharyngeal candidiasis, dysphonia, skin atrophy, impaired wound healing, hypertension, fluid retention, immunosuppression, cataracts, hyperglycemia, hypercortisolism, Depression, euphoria, osteoporosis, growth retardation in children, muscle atrophy,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 503   Edition : 3,

►  Drug Interaction : Drug interaction of Flunisolide is with NA

  ►    Mechanism of Drug Drug Interaction :  Aerosol treatment is the most effective way to avoid the systemic adverse effects of corticosteroid therapy. The introduction of corticosteroids such as beclomethasone, budesonide, flunisolide, & fluticasone, has made it possible to deliver corticosteroids to the airways with minimal systemic absorption. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 347   Edition : 12,


►  Contraindication : Systemic fungal infection,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 503   Edition : 3,
  ►  Mechanism of Action :   Multiple mechanisms are involved in the suppression of inflammation by glucocorticoids. Glucocorticoids inhibit the production by multiple cells of factors that are critical in generating the inflammatory response. As a result, there is decreased release of vasoactive and chemoattractive factors, diminished secretion of lipolytic and proteolytic enzymes, decreased extravasation of leukocytes to areas of injury, and ultimately, decreased fibrosis. Glucocorticoids can also reduce expression of pro-inflammatory cytokines, as well as COX-2 and NOS2. The net effect of these actions on various cell types is to diminish markedly the inflammatory response. ,
Ref :-   Book : Goodman    Page : 1221,1222   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1670   Edition : 37,


►    Plasma Half-life :
  Min value :-   4 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1670   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,