Fluoxetine is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 430   Edition : 37,

  ►   Brandname : Depzac,Fludac,Auscap,Prozac,Prozit,Sarafem,Fluctin,Ao Mai Lun

  ►  Strength : Capsule with 10  mg, Capsule with 20  mg, Capsule with 40  mg, Oral liquid with 20  mg/5mL, Tablet with 10  mg, Tablet with 20  mg, Delayed-release capsules with 90  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 417   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 20 mg Capsule o.d. If no clinical response is seen after several weeks, the daily dose may be gradually increased, up to a maximum of 80 mg daily (60 mg in the elderly). Doses above 20 mg daily may be given in 2 divided doses.
2 Bulimia nervosa Oral 60 mg It may be given daily as a single morning dose or in divided doses.
3 Obsessive-compulsive disorder Oral 20 mg Capsules o.d. It may be increased after several weeks if there is no response to up to 60 mg daily.
4 Panic disorder Oral 10 mg Capsules o.d. After a week the dose should be increased to 20 mg daily; further increases to 60 mg daily may be considered after several weeks if no improvement is seen.
5 Premenstrual dysphoric disorder Oral 20 mg Capsule Intermittent dosing is also permitted: for each new cycle, fluoxetine should be started 14 days before the onset of menstruation and continued until the first full day of menstruation. Treatment may be continued for 6 months; benefit should then be reassessed before continuing further.

Ref :-  Book : Martindale    Page : 417   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression 8 Year above 8 Year Oral 10 mg Oral liquid
2 Obsessive-compulsive disorder 7 Year over 7 Year Oral 10 mg Oral liquid

Ref :- Book : Martindale    Page : 417   Edition : 38,
►  Side Effect : GI distress, sexual dysfunction, vasospasm, sweating, Somnolence, anxiety, serotonin syndrome from concomitant administration of MAOI, characterised by hyperthermia, Muscle rigidity, myoclonus, and rapid fluctuations in mental status and vital signs,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 221   Edition : 3,

►  Drug Interaction : Drug interaction of Fluoxetine is with , ,  NA

  ►    Mechanism of Drug Drug Interaction :  SSRIs interact with other drugs mainly as a result of their inhibitory activity on hepatic cytochrome P450 isoenzymes. Individual SSRIs do not all exhibit the same degree of inhibition nor do they react with the same isoenzymes. The drugs inhibited by specific SSRIs depends on the isoenzyme affected. As SSRIs have occasionally been associated with bleeding disorders and other effects on the blood, caution is advised when they are given with drugs known to affect platelet function. Although different antidepressants have been used together under expert supervision in refractory cases of depression, severe adverse reactions including the serotonin syndrome may occur. Sequential prescribing of different types of antidepressant may also produce adverse reactions. At least one week should elapse between withdrawing an SSRI and starting any drug liable to provoke a serious reaction (e.g. phenelzine); for fluoxetine 5 weeks, because of their longer half-lives. Adverse effects such as the serotonin syndrome may also occur when the SSRIs are given with other drugs known to act on the same neurotransmitter, a consequence of synergistic interaction.,
Ref :-   Book : Martindale    Page : 424   Edition : 38,


►  Contraindication : Treatment should be stopped if seizures develop or when there is an increase in seizure frequency, stopped if skin rash occurs, SSRIs may impair performance of skilled tasks and, if affected, patients should not drive or operate machinery,
Ref :-   Book : Martindale    Page : 422   Edition : 38,
  ►  Mechanism of Action :   Selectively inhibit reuptake of serotonin and therby increase synaptic serotonin level; also cause increased 5-HT receptor activation and enhanced postsynaptic responses. At high dose, also bind on NE transporter.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 221   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Brahmine with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antidepressants . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BELLABONNA with Increasing anticholinergic activity of tricyclic antidepressants ., CANNABIS with cannabis having tetrahydrocannabinol a potent inhibitor of serotonin uptake ., EPIMEDIUM I.E. EPIMEDIUM BREVICORNU with inhibit CYP2D6, KAVA KAVA with Coma, sedation, lethargy, drowsiness .,

      ►  Reference :-
  • Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C.
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://www.crcnetbase.com/doi/pdf/10.1201/9781420040463.fmatt, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 428   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   6 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 428   Edition : 37,