Flupentixol is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1075   Edition : 38  

  ►   Brandname : Fluanxol, Depixol
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1075   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM
Reference :-   Book : Martindale    Page : 1074   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Psychoses Oral 3 18 mg b.d. The initial dose in elderly and debilitated patients may need to be reduced to a quarter or a half of the usual starting dose. If given by deep intramuscular injection, an initial test dose of 20 mg of the decanoate, as 1 mL of a 2% oily solution, is used. Then after at least 7 days and according to response, this may be followed by doses of 20 to 40 mg every 2 to 4 weeks. Shorter dosage intervals or greater amounts may be required according to the patient’s response. The initial dose in elderly and debilitated patients may need to be reduced to a quarter or a half of the usual starting dose. If doses greater than 40 mg (2 mL) are considered necessary they should be divided between 2 separate injection sites.
2 Mild to moderate depression, with or without anxiety Oral 1 mg Dose expressed in terms of the equivalent amount of Flupentixol; (0.5 mg used in the elderly) Given daily, increased after 1 week to 2 mg (1 mg in the elderly) and then to a maximum of 3 mg (2 mg in the elderly) daily. Doses above 2 mg (1 mg in the elderly) should be given in 2 divided doses. The last dose of the day should be given no later than 4 p.m. and if no effect has been noted within 1 week of reaching the maximum dose, treatment should be withdrawn.

Ref :-  Book : Martindale    Page : 1074   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Less sedation, Extrapyramidal effects are more frequent, Other side effects as for Chlorpromazine
Ref :-   Book : Martindale    Page : 1047,1074   Edition : 38.  

►  Drug Interaction : Drug interaction of Flupentixol is with , Dopamine agonists, , , , , Antimalarials, , Tricyclic antidepressants,  Metoclopramide , Cisapride
Ref :-   Book : Martindale    Page : 1076   Edition : 37.   Martindale    Page : 1051,1052,1074   Edition : 38.   Martindale    Page : 1051,1052,1074   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  The most common interactions encountered with thioxanthenes result from use with drugs that have similar pharmacological actions. In theory, antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic. Use with metoclopramide may increase the risk of antipsychotic-induced extrapyramidal effects. There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval. Most
Ref :-   Book : Martindale    Page : 1051,1052,1074   Edition : 38.  

►  Contraindication : States of excitement or overactivity, including mania
Ref :-   Book : Martindale    Page : 1074   Edition : 38.  
  ►  Mechanism of Action :   Flupentixol is a thioxanthene antipsychotic. It is a dopamine inhibitor; the turnover of dopamine in the brain is also increased. There is some evidence that the antagonism of central dopaminergic function, especially at the D2-dopaminergic receptor, is related to therapeutic effect in psychotic conditions.
Ref :-   Book : Martindale    Page : 1045,1074   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway.  

  ►  Pathway with its reference as follows :-
  • antipsychotic neuroleptic . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine antagosit drug.   EVENING PRIMROSE OIL with Potential risk of seizures.   KAVA with Cause excessive drawsiness.   KAVA KAVA with Coma, sedation, lethargy, drowsiness.  

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 1101   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   35 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1101   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1101   Edition : 37.