Fluphenazine is a Medicine belongs to Antipsychotics group whose information about Brand can be referenced from   Book : Martindale    Page : 1076   Edition : 38,

  ►   Brandname : Anatensol,Fludecan,Modecate,Lyogen,Deca,Flumezin

  ►  Strength : Injection with 25  mg/ml, Tablet with 1  mg, Tablet with 2.5  mg, Tablet with 5  mg, Tablet with 10  mg, Elixir with 2.5  mg/5mL, Injection with 2.5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, SC,
Reference :-   Book : Martindale    Page : 1075   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Psychoses Oral 2.5 10 mg Tablet Given daily in divided doses every 6 to 8 hours, for treatment of schizophrenia, mania, and other psychoses.
2 Psychoses IM 2.5 10 mg Injection Given daily in divided doses every 6 to 8 hours for the treatment of schizophrenia, mania, and other psychoses. The long-acting decanoate or enantate esters of fluphenazine are usually given by deep i.m injection and are used mainly for the maintenance treatment of patients with schizophrenia or other chronic psychoses. An initial dose of fluphenazine decanoate 12.5 mg (6.25 mg in the elderly).

Ref :-  Book : Martindale    Page : 1075   Edition : 38,

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : less likely to cause sedation, hypotension, or antimuscarinic effects, higher incidence of extrapyramidal effects, Other side effects as for Chlorpromazine,
Ref :-   Book : Martindale    Page : 1075   Edition : 38,

►  Drug Interaction : Drug interaction of Fluphenazine is with Alcohol, General anaesthetics , Hypnotics, Anxiolytics, Opioids, , , Tricyclic antidepressants, , , , , , , Antimalarials, , ,  Guanethidine, Metoclopramide , Cisapride ,
Ref :-   Book : Martindale    Page : 1051,1052,1075   Edition : 38, Martindale    Page : 1051,1052,1074   Edition : 38,

  ►    Mechanism of Drug Drug Interaction :  The most common interactions encountered with phenothiazines such as chlorpromazine result from use with drugs that have similar pharmacological actions. Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. When given with other drugs that produce orthostatic hypotension, dosage adjustments may be necessary. However, it should be noted that phenothiazines have been reported to reduce the antihypertensive action of guanethidine and other adrenergic neurone blockers. As many phenothiazines possess antimuscarinic actions they can potentiate the adverse effects of other drugs with antimuscarinic actions, including tricyclic antidepressants and the antimuscarinic antiparkinsonian drugs that may be given to treat phenothiazine-induced extrapyramidal effects. In theory, antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic. Use with metoclopramide may increase the risk of antipsychotic-induced extrapyramidal effects. There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval. Fluphenazine is metabolised by the cytochrome P450 isoenzyme CYP2D6 and is itself an inhibitor of this enzyme; other substrates or inhibitors of CYP2D6 may increase plasma concentrations and prolong the effects of fluphenazine.,
Ref :-   Book : Martindale    Page : 1051,1052,1075   Edition : 38,

►  Contraindication : Bone marrow suppression, pre-existing CNS depression or coma, phaeochromocytoma, prolactin-dependent tumours, impaired cardiovascular function, impaired cerebrovascular function, impaired kidney function, impaired liver function, impaired respiratory function, angle-closure glaucoma, History of jaundice, paralytic ileus, parkinsonism, prostatic hyperplasia, Diabetes mellitus, Hypothyroidism, myasthenia gravis, urinary retention,
Ref :-   Book : Martindale    Page : 1050,1075   Edition : 38,
  ►  Mechanism of Action :   Fluphenazine is a phenothiazine antipsychotic. It is a dopamine inhibitor; the turnover of dopamine in the brain is also increased. There is some evidence that the antagonism of central dopaminergic function, especially at the D2-dopaminergic receptor, is related to therapeutic effect in psychotic conditions.,
Ref :-   Book : Martindale    Page : 1045   Edition : 38,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antipsychotic effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,

    Dietry Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication Dietry Substance

    ​   ► This Medicine contraindicate with :- EVENING PRIMROSE OIL with Potential risk of seizures, KAVA with Cause excessive drawsiness, KAVA KAVA with Coma, sedation, lethargy, drowsiness,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal, Fecal,
    Ref :-   Book : Martindale    Page : 1076   Edition : 38,

    ►    Plasma Half-life :   Min value :-   14.7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1102   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,