Flurazepam is a Medicine belongs to Hypnotics group whose information about Brand can be referenced from   Book : Martindale    Page : 1076   Edition : 38,

  ►   Brandname : Fluraz,Dalmane,Dalmadorm,Fluracap,Benozil

  ►  Strength : Capsule with 15  mg, Capsule with 30  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1076   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Short-term management of insomnia Oral 15 30 mg Capsule Dose given at night. A maximum initial dose of 15 mg has been suggested for elderly or debilitated patients.

Ref :-  Book : Martindale    Page : 1076   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : excessive somnolence, fatigue, headache, respiratory depression, Apnoea, desaturation in pediatric patients, agitation,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 183   Edition : 3,

►  Drug Interaction : Drug interaction of Flurazepam is with Alcohol, antidepressants, Sedative antihistamines, Antipsychotics, General anaesthetics , , opioid analgesics, ,  NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. The metabolism of most benzodiazepines is mediated primarily by the cytochrome P450 system, particularly the isoenzyme CYP2C19 and CYP3A4. Hence, adverse effect may also be produced by use with drugs that inhibit or induce or are metabolised by these isoenzyme. Benzodiazepines such as alprazolam, diazepam and midazolam that are metabolised primarily by hepatic microsomal oxidation may be more susceptible to pharmacokinetic changes than those eliminated mainly by glucuronide conjugation such as lorazepam, oxazepam, and temazepam.,
Ref :-   Book : Martindale    Page : 1068,1076   Edition : 38,


►  Contraindication : as given in diazepam,
Ref :-   Book : Martindale    Page : 1066,1076   Edition : 38,
  ►  Mechanism of Action :   Bind to specific GABAA receptor subunits at Central nervous system (CNS) neuronal synapses facilitating frequency of GABA- mediated chloride ion channel opening-enhance membrane hyperpolarization,
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1076   Edition : 38,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   30 min,    Max value :-   60 min,
Ref :-   Book : Martindale    Page : 1076   Edition : 38,