Flurbiprofen is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 65   Edition : 38  

  ►   Brandname : Arflur, Cadiflur, Froben, Ocufen, Strepfen, Dobendan Direkt, Kai Fen, Ropion
  ►  Strength : Tablet with 50 mg.  Tablet with 100 mg.  Ophthalmic Solution with 0.03 %.  Suppository with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12   Martindale    Page : 65   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, rectal
Reference :-   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12   Martindale    Page : 65   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Intra-operative miosis Topical 0.03 % Eye Drop For intra-operative miosis during ocular surgery, one drop is instilled into the eye every 30 minutes beginning 2 hours before surgery and ending not less than 30 minutes before surgery. To control postoperative inflammation the same dosage regimen is used before ocular surgery followed 24 hours after surgery by the instillation of one drop 4 times daily for 1 to 3 weeks. Flurbiprofen sodium eye drops have also been used in the topical treatment of cystoid macular oedema.
2 Pain and inflammation Oral 150 300 mg Tablet Given daily in divided doses. Doses may be increased to 300 mg daily in acute or severe conditions if necessary. Patients with dysmenorrhoea may be given an initial dose of 100 mg followed by 50 to 100 mg every four to six hours to a maximum total daily dose of 300 mg.
3 sore throat Oral 8.75 mg Lozenge It may be sucked or allowed to dissolve slowly in the mouth every 3 to 6 hours to a maximum daily dose of 5 lozenges. It is recommended that treatment should be limited to a maximum of 3 days.

Ref :-  Book : Martindale    Page : 65   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Gastrointestinal disturbance, Tinnitus, Serious:, Gastrointestinal haemorrhage, Gastrointestinal ulceration, Gastrointestinal perforation, Nephrotoxicity, Stevens-Johnson syndrome
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3.  

►  Drug Interaction : Drug interaction of Flurbiprofen is with Cardiac Glycosides, Angiotensin converting enzyme inhibitor, Diuretics, Potassium -Sparing Diuretics , Beta Blockers , Quinolones, sulfonylurea antidiabetic , , selective serotonin reuptake inhibitors, , Alcohol, Bisphosphonates,  Aspirin, Clopidogrel , Ticlopidine , Corticosteroids, Methotrexate, Azapropazone, Phenylbutazone, Lithium carbonate , Cyclosporine , Tacrolimus , Phenytoin , Venlafaxine , Iloprost , Sibutramine, Pentoxifylline , Zidovudine, Ritonavir, Mifepristone , Misoprostol
Ref :-   Book : Martindale    Page : 66,107,108   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. Effects on renal function may lead to reduced excretion of some drugs. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassiumsparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. Convulsions may occur due to an interaction with quinolones. NSAIDs may increase the effects of phenytoin and sulfonylurea antidiabetics. Use of more than one NSAID together (including aspirin) should be avoided because of the increased risk of adverse effects. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. There may be an increased risk of haematotoxicity if zidovudine is used with NSAIDs. Ritonavir may increase the plasma concentrations of NSAIDs. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by NSAIDs or aspirin may alter the efficacy of mifepristone. There have been occasional reports of increased adverse effects when NSAIDs were given with misoprostol although such combinations have sometimes been used to decrease the gastrointestinal toxicity of NSAIDs.
Ref :-   Book : Martindale    Page : 108   Edition : 38.  

►  Contraindication : Asthma, Coagulation defect, Allergic reactions after taking NSAIDS, Urticaria, Risk of severe, even fatal anaphylactic reactions, Gastrointestinal or intracranial bleeding, Significant renal insufficiency
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3.  
  ►  Mechanism of Action :   Flurbiprofen is a propionic acid derivative with a possibly more complex mechanism of action than other NSAIDs. Its ( S )(–) enantiomer inhibits COX nonselectively, but it has been shown in rat tissue to also affect tumor necrosis factor-α (TNF-α) and nitric oxide synthesis.
Ref :-   Book : Basic & Clinical pharmacology    Page : 641   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fish with Another pathway.  

  ►  Pathway with its reference as follows :-
  • eicosapentaenoic acid have Anti-inflammatory --- (19. Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart )

  •   ►  URL --
  • https://books.google.co.in/books?id=QP3AhXa9YsAC&printsec=frontcover&dq=19.%09Michael .
  • +Z.+(2007).+Hand+book+of+nutrition.+New+York:+Thieme+Stuttgart&hl=en&sa=X&redir_esc=y#v=onepage&q&f=false .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- LITHIUM with Most NASDs inhibit the exretion of lithium from the body , resulting in higher blood levels of the mineral , though sulindac ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 66   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   6 hours.  
    Ref :-   Book : Martindale    Page : 66   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 66   Edition : 38.