Folic acid is a Medicine belongs to Vitamin group whose information about Brand can be referenced from   Book : Martindale    Page : 2101   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Folet,Folvite,Megafol,Ingafol,DreisaFol,Folicare,A to Z,A to Z Gold,Becosule ,Betonin,Orofer xt,Felicita,Ferrovit,Gembone,Reheptin ,health ok,Meganeuron Plus ,Unicobal forte,Vitcofol,Nurokind Gold,Nurokind-LC,Nurokind Next,Wellwoman tablet

  ►  Strength : Tablet with 0.4  mg, Tablet with 0.8  mg, Tablet with 1  mg, Injection with 5  mg/ml, Capsule with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 598   Edition : 12, Martindale    Page : 2066   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, s.c, i.v, i.m,
Reference :-   Book : Martindale    Page : 2063   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Folate-deficient megaloblastic anaemia Oral 5 mg Tablet Given daily for 4 months; up to 15 mg daily may be necessary in malabsorption states.
2 Folate-deficient megaloblastic anaemia Oral 5 mg Tablet Given every 1 to 7 days may be necessary in chronic haemolytic states such as thalassaemia major or sickle-cell anaemia, depending on the diet and rate of haemolysis; similar doses may be necessary in some patients receiving renal dialysis in order to prevent deficiency.
3 Folate deficiency Oral 0.25 1 mg Tablet Given daily. This dose is suggested until a haematopoietic response has been obtained, although some patients require higher doses, especially in malabsorption states. The usual maintenance dose is 400 micrograms daily.
4 Folate deficiency 4 5 mg For women of child-bearing potential at high risk of having a pregnancy affected by neural tube defect. Dose (given daily and) started before pregnancy and continued through the first trimester. For other women of child-bearing potential the dose is 400 micrograms daily.

Ref :-  Book : Martindale    Page : 2063   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Folate-deficient megaloblastic anaemia neonate 1 Year Oral 500 micrograms/kg
2 Folate-deficient megaloblastic anaemia 1 Year 18 Year Oral
3 Haemolytic anaemia, metabolic disorders 1 Month 12 Year Oral 2.5 5 mg
4 Haemolytic anaemia, metabolic disorders 12 Year 18 Year Oral 5 10 mg Tablet
5 Prophylaxis of folate deficiency in dialysis 1 Month 12 Year Oral 250 micrograms/kg
6 Prophylaxis of folate deficiency in dialysis 12 Year 18 Year Oral 5 10 mg Tablet

Ref :- Book : Martindale    Page : 2063   Edition : 38,
►  Side Effect : ,
Ref :-   Book :    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Folic acid is with Antiepileptics , oral contraceptives, , Alcohol, , Sulfonamides ,  Methotrexate, Pyrimethamine , Triamterene , Trimethoprim , Phenytoin ,
Ref :-   Book : Martindale    Page : 2066   Edition : 38, Martindale    Page : 2066   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Folate deficiency states may be produced by drugs such as antiepileptics, oral contraceptives, antituberculous drugs, alcohol, glucarpidase, and folic acid antagonists such as methotrexate, pyrimethamine, triamterene, trimethoprim, and sulfonamides. In some instances, such as during methotrexate or antiepileptic therapy, replacement therapy with folinic acid or folic acid may become necessary in order to prevent megaloblastic anaemia developing; folate supplementation has reportedly decreased serum-phenytoin concentrations in a few cases and there is a possibility that such an effect could also occur with barbiturate antiepileptics.,
Ref :-   Book : Martindale    Page : 2066   Edition : 38,


►  Contraindication : Should never be given alone or with inadequate amounts of vitamin B12 for the treatment of undiagnosed megaloblastic anaemia,
Ref :-   Book : Martindale    Page : 2065   Edition : 38,
  ►  Mechanism of Action :   Folic acid is reduced in the body to tetrahydrofolate, which is a coenzyme for various metabolic processes including the synthesis of purine and pyrimidine nucleotides, and hence in the synthesis of DNA; it is also involved in some amino-acid conversions, and in the formation and utilisation of formate.,
Ref :-   Book : Martindale    Page : 2099   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Dark green leafy vegetable with same compound,

  ►  Pathway with its reference as follows :-
  • Nutritional Supplement --- ( Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )

  •   ►  URL -- https://books.google.co.in/books/about/Nutritive_Value_of_Indian_Foods.html?id=biFBAAAAYAAJ,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 2098   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA