Fondaparinux is a Medicine belongs to Anticoagulant group whose information about Brand can be referenced from   Book : Martindale    Page : 1386   Edition : 38,

  ►   Brandname : Arixtra

  ►  Strength : Injection with 2.5  mg, Injection with 5  mg, Injection with 7.5  mg, Injection with 10  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, IV,
Reference :-   Book : Martindale    Page : 1420   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of venous thromboembolism SC 2.5 mg Injection o.d. Used in case of abdominal and orthopaedic surgery; Therapy started at least 6 to 8 hours after surgery and continued for at least 5 to 9 days or up to 32 days in hip fracture. For prophylaxis in high-risk medical patients, the same dose is given once daily for 6 to 14 days.
2 Treatment of venous thromboembolism SC 5 mg Injection o.d. Above dose given to patients weighing less than 50 kg, 7.5 mg for weight 50 to 100 kg, and 10 mg for weight over 100 kg. Treatment is usually continued for 5 to 9 days, and at least until oral anticoagulation is established.
3 Used in unstable angina and acute ST-elevation myocardial infarction IV 2.5 mg Injection o.d. It is only indicated in patients for whom urgent percutaneous coronary intervention is not planned. And given in the above dose for up to 8 days, with the first dose given intravenously in acute ST-elevation myocardial infarction. Heparin should be given at the time of the procedure if percutaneous coronary intervention is performed and fondaparinux should be restarted when clinically appropriate.

Ref :-  Book : Martindale    Page : 1385   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Haemorrhage, thrombocytopenia, hypersenstivity, skin necrosis, Alopecia and osteoporosis resulting in spontaneous fractures have occurred after prolonged use, hyperkalaemia, hypersensitivity reactions, local irritation, platelet aggregation, thrombosis,
Ref :-   Book : Martindale    Page : 1420,1431   Edition : 37,

►  Drug Interaction : Drug interaction of Fondaparinux is with , Non Sterodial Anti- Inflammatory Drugs , , , , , ,  Aspirin, Dipyridamole , Dextran, Streptokinase ,
Ref :-   Book : Martindale    Page : 1420,1433   Edition : 37, Martindale    Page : 1433   Edition : 37, Martindale    Page : 1420,1431   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  It should be used with care with oral anticoagulants or drugs, such as aspirin and dipyridamole, that affect platelet function. NSAIDs may also increase the risk of haemorrhage. Other drugs that affect the coagulation process and which may therefore increase the risk of haemorrhage include dextrans, thrombolytic enzymes such as streptokinase, high doses of penicillins and some cephalosporins, some contrast media, asparaginase, and epoprostenol.,
Ref :-   Book : Martindale    Page : 1420,1433   Edition : 37,


►  Contraindication : severe renal disease, patients who have developed thrombocytopenia with heparin, who have a positive in-vitro platelet aggregation test (that is, cross-reactivity) in the presence of fondaparinux itself, and special care is required in patients with body-weight below 50 kg,
Ref :-   Book : Martindale    Page : 1386   Edition : 38,
  ►  Mechanism of Action :   Fondaparinux is a synthetic pentasaccharide anticoagulant that acts as a selective inhibitor of factor Xa (activated factor X).,
Ref :-   Book : Martindale    Page : 1385   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1420   Edition : 37,


►    Plasma Half-life :
  Min value :-   17 hours,    Max value :-   21 hours,
Ref :-   Book : Martindale    Page : 1420   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,