Foscarnet is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 982   Edition : 38,

  ►   Brandname : Foscavir,Anji

  ►  Strength : Injection with 24  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 969   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 CMV retinitis IV infusion 60 mg/kg Injection Above dose given to patients with normal renal function and infused over at least 1 hour every 8 hours, or 90 mg/kg infused over 1 and a half to 2 hours every 12 hours, for 2 to 3 weeks; this should then be followed by maintenance therapy with 60 mg/kg daily, increasing to 90 to 120 mg/kg daily infused over 2 hours if tolerated.
2 Herpes simplex infections IV infusion 40 mg/kg Injection Above dose given for Aciclovir-resistant mucocutaneous herpes infection in patients with normal renal function; infused over at least 1 hour every 8 or 12 hours for 2 to 3 weeks or until lesions have healed.

Ref :-  Book : Martindale    Page : 981   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acyclovir-resistant VZV infection IV 120 mg/kg/day Injection

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1108   Edition : 19,
►  Side Effect : serious common adverse effect is renal impairment, granulocytopenia and thrombocytopenia have been reported, Other include nausea, vomiting, diarrhea, malaise, fatigue, fever, headache, Dizziness, paraesthesia, tremor, mood disturbances, rash, abnormal liver fuction tests, blood pressure and ECG changes, isolated reports of pancreatitis., Anaemia may be common, may be associated with an acute decrease in ionised calcium in the plasma, Other electrolyte disturbances may occur, phlebitis at the site of injection,
Ref :-   Book : Martindale    Page : 969   Edition : 37,

►  Drug Interaction : Drug interaction of Foscarnet is with Aminoglycoside antibiotic , ,  Amphotericin B , Cyclosporine , Pentamidine ,
Ref :-   Book : Martindale    Page : 968   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Foscarnet should not be given with other nephrotoxic drugs such as aminoglycosides, amphotericin B, and ciclosporin, or with other drugs that can affect serum calcium concentrations. Intravenous pentamidine can produce both of these effects and severe additive toxicity may result from its use with foscarnet; fatalities have occurred.,
Ref :-   Book : Martindale    Page : 969   Edition : 37,


►  Contraindication : Safety in pregnancy or childhood is uncertain,
Ref :-   Book : Goodman    Page : 1603   Edition : 12,
  ►  Mechanism of Action :   Foscarnet (phosphonoformic acid) is an inorganic pyrophosphate analog that inhibits herpesvirus DNA polymerase, RNA polymerase, and HIV reverse transcriptase directly without requiring activation by phosphorylation. Foscarnet blocks the pyrophosphate binding site of these enzymes and inhibits cleavage of pyrophosphate form deoxynucleotide triphosphates.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 868   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway, with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-Viral effect --- (Quan, F. (2015). Salviae and Cinnamomi Herbal Medicines have Antiviral Activity against a Broad Range of Human Immunodeficiency Viru. International Journal Of Virology And AIDS, 1(2). )
  • Triterpene saponins have Anti viral effect --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )

  •   ►  URL -- http://clinmedjournals.org/articles/ijva/international-journal-of-virology-and-aids-ijva-2-013.pdf, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 969   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA