Fosinopril sodium is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1386   Edition : 38  

  ►   Brandname : Fovas, Fosipril, Monopril, Fosinace
  ►  Strength : Tablet with 10 mg.  Tablet with 20 mg.  Tablet with 40 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 224   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1421   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 10 40 mg Tablet o.d. Since there may be a precipitous fall in blood pressure in some patients when starting therapy with an ACE inhibitor, the first dose should preferably be given at bedtime. In patients already taking diuretic therapy the diuretic should be withdrawn if possible several days before starting fosinopril, and resumed later if necessary.
2 Heart failure Oral 10 40 mg Tablet o.d. In the management of heart failure, severe first-dose hypotension on introduction of an ACE inhibitor is common in patients on loop diuretics, but their temporary withdrawal may cause rebound pulmonary oedema. Thus treatment should begin with a low dose under close medical supervision. An initial dose of 5 mg may be given in patients at high risk of hypotension.

Ref :-  Book : Martindale    Page : 1386   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 0.1 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19  
►  Side Effect : Hypotension, Cough, Edema, Rashes, Gynaecomastia, Hyperkalaemia, Neutropenia, Agranulocytosis, Angioedema (more frequent in black patients), Proteinuria
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3.  

►  Drug Interaction : Drug interaction of Fosinopril sodium is with Diuretics, , Alcohol, , Potassium -Sparing Diuretics , , , NONSTEROIDAL ANTI-INFLAMMATORY DRUGS,  Losartan , Aliskiren Fumarate
Ref :-   Book : Martindale    Page : 1288,1386,1424   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Excessive hypotension may occur when ACE inhibitors are used with diuretics, other antihypertensives, or other agents, including alcohol, that lower blood pressure. An additive hyperkalaemic effect is possible in patients receiving ACE inhibitors with potassium sparing diuretics, potassium supplements (including potassium-containing salt substitutes), or other drugs that can cause hyperkalaemia (such as ciclosporin or indometacin), and serum-potassium concentrations should be monitored. Potassium-sparing diuretics and potassium supplements should generally be stopped before starting ACE inhibitors in patients with heart failure. However, ACE inhibitor therapy does not obviate the possible need for potassium supplementation in patients given potassium-wasting diuretics and potassium concentrations should also be monitored in these patients. The adverse effects of ACE inhibitors on the kidneys may be potentiated by other drugs, such as NSAIDs, that can affect renal function. The use of losartan with an ACE inhibitor may increase the risk of hyperkalaemia, hypotension, and syncope, particularly in patients with atherosclerotic disease or heart failure or in diabetics who have end-organ damage. The use of ACE inhibitors with the renin inhibitor aliskiren is generally not recommended, and should be avoided in some patients.
Ref :-   Book : Martindale    Page : 1288,1386,1424   Edition : 38.  

►  Contraindication : Pregnancy, Renal impairment, History of angioedema, Bilateral renal artery stenosis
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3.  
  ►  Mechanism of Action :   Inhibition of ACE decreases conversion of angiotensin (AT) to ATII, And thereby decreases arteriolar vasoconstriction, Aldosetrone synthesis, renal proximal tubule NaCl reabsorption, and ADH release. ACE inhibitors also inhibit the degradation of bradykinin, and thereby increase vasodilation.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Rhazya stricta with same pathway.   Achillea fragrantissima with same pathway.   Moringa peregrina with same pathway.  

  ►  Pathway with its reference as follows :-
  • Moringa peregrina act as ACE inhibitor. --- ( Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. )
  • Rhazya stricta act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. )

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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Enhancer.   POTASSIUM with Dietary Substance is Drug Inhibitor.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL --

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- POTASSIUM with Increase the risk of hyperkalemia ..  

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL --

    ►   Route of Elimination :   Biliary, Fecal, Renal
    Ref :-   Book : Martindale    Page : 1291   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   3 hours for metabolite fosinoprilat.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1386   Edition : 38.