Fosinopril sodium is a Medicine belongs to Angiotensin conveting enzyme inhibitors group whose information about Brand can be referenced from   Book : Martindale    Page : 1421   Edition : 37,

  ►   Brandname : Fovas,Staril,Monopril

  ►  Strength : Tablet with 10  mg, Tablet with 20  mg, Tablet with 40  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 224   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1421   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 10 mg Tablet o.d.
2 Heart failure Oral 10 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1421   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 0.1 mg/kg o.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19,
►  Side Effect : hypotension, Dizziness, fatigue, headache, nausea, gastrointestinal disturbance, tachycardia, palpitations, chest pain, hyperkalaemia, hyponatraemia, neutropenia, agranulocytosis, stomatitis, abdominal pain, Pancreatitis, hepatotoxicity, Cough, severe muscle pain, angioedema, Anaphylactoid reactions,
Ref :-   Book : Martindale    Page : 1315,1316   Edition : 37,

►  Drug Interaction : Drug interaction of Fosinopril sodium is with Tenecteplase , Clopamide , Zonisamide , Fosinopril sodium , Sildenafil , Cyclosporine , Digoxin , Spironolactone , Epoetin alfa , Testosterone , Interferon, interleukin-3, Felbamate, Indomethacin , Ropivacaine ,
Ref :-   Book : Martindale    Page : 1318   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Excessive hypotension may occur when ACE inhibitors are used with diuretics, other antihypertensives, or other agents, including alcohol, that lower blood pressure. The bioavailability of fosinopril, and possibly other ACE inhibitors, may also be reduced by use with antacids. An additive hyperkalaemic effect with ACE inhibitors and ciclosporin is possible. For reports of an increase in serum-digoxin concentrations during therapy with ACE inhibitors. Excessive hypotension may occur when ACE inhibitors are used with diuretics. Severe hyperkalaemia may occur if ACE inhibitors are used with spironolactone. ACE inhibitors have also been reported to antagonise the haematopoietic effects of epoetins. Marked hypotension may occur during general anaesthesia in patients taking ACE inhibitors. Severe granulocytopenia has been reported in 3 patients with mixed cryo globulinaemia treated with interferon alfa-2a who also received ACE inhibitors. Marked hypotension occurred in 3 patients1 receiving ACE inhibitors who were given interleukin-3 following chemotherapy; blood pressure returned to normal when the ACE inhibitors were stopped. For reports of lithium toxicity in patients taking ACE inhibitors. Indometacin and possibly other NSAIDs, including aspirin, have been reported to reduce or abolish the hypotensive action of ACE inhibitors.,
Ref :-   Book : Martindale    Page : 1318   Edition : 37,


►  Contraindication : pregnancy, renal impairment,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,
  ►  Mechanism of Action :   Inhibition of ACE decreases conversion of angiotensin (AT) to ATII, and thereby decreases arteriolar vasoconstriction, aldosetrone synthesis, renal proximal tubule NaCl reabsorption, and ADH release. ACE inhibitorsalso inhibit the degradation of bradykinin, anthereby increase vasodilation. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Rhazya stricta with same pathway, Achillea fragrantissima with same pathway, Moringa peregrina with same pathway,

  ►  Pathway with its reference as follows :-
  • Rhazya stricta act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Achillea fragrantissima act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Moringa peregrina act as ACE inhibitor. --- ( Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )

  •   ►  URL -- http://www.academicjournals.org/journal/JMPR/article-abstract/3FB279457381,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Enhancer, POTASSIUM with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- POTASSIUM with Increase the risk of hyperkalemia .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1291   Edition : 37,


    ►    Plasma Half-life :   Min value :-   11.5 hours,    Max value :-   14 hours,
    Ref :-   Book : Martindale    Page : 1291   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1291   Edition : 37,