Fosphenytoin is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 523   Edition : 38,

  ►   Brandname : Fosolin, Fosphen, Pro-Epanutin, Cerebyx, Fostoin.

  ►  Strength : Injection with 75  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 525   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tonic-clonic status epilepticus IV infusion 15 mg/kg Injection In the treatment of tonic-clonic status epilepticus a benzodiazepine such as diazepam or lorazepam is usually given initially intravenously or rectally followed by fosphenytoin. It is given as a loading dose in PSE (phenytoin sodium equivalents) as a single dose at a rate of 100 to 150 mg/minute.
2 Seizures i.m or i.v 10 15 mg/kg Injection For seizures other than in status epilepticus; Above given doses are the loading dose given as a single dose at a rate of 50 to 100 mg/minute.

Ref :-  Book : Martindale    Page : 523   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tonic-clonic status epilepticus IV infusion 15 mg/kg Injection
2 Treatment or prophylaxis of seizures other than in status epilepticus IV infusion 10 15 mg/kg Injection

Ref :- Book : Martindale    Page : 523   Edition : 38,
►  Side Effect : ataxia, nystagmus, gingival hyperplasia, incoordination, Hirsutism, Confusion, facial coarsening, agranulocytosis, leucopenia, Stevens-Johnson syndrome, toxic epidermal necrolysis, pancytopenia, thrombocytopenia, megaloblastic anaemia, hepatitis,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 236   Edition : 3,

►  Drug Interaction : Drug interaction of Fosphenytoin is with , , , , Anticoagulant , Corticosteroids, ,  Lidocaine , Dopamine , Quinidine ,
Ref :-   Book : Martindale    Page : 523,542   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  There are complex interactions between antiepileptics, and toxicity may be enhanced without a corresponding increase in antiepileptic activity. Such interactions are very variable and unpredictable and plasma monitoring is often advisable with combination therapy. Since phenytoin is extensively bound to plasma proteins it can be displaced by drugs competing for protein- binding sites, thus liberating more free (pharmacologically active) phenytoin into the plasma. However, elevation of free phenytoin is reported to be of little clinical significance provided hepatic function is not impaired. A potentially more serious type of interaction may occur because Phenytoin metabolism is saturable: toxic concentrations of Phenytoin can develop in patients given drugs that inhibit phenytoin metabolism even to quite a minor degree. Phenytoin itself is also a potent enzyme inducer, and induces the metabolism of a number of drugs, including some antibacterials, anticoagulants, corticosteroids, quinidine, and sex hormones (notably, oral contraceptives). The hypotensive properties of dopamine and the cardiac depressant properties of drugs such as lidocaine may be dangerously enhanced by intravenous phenytoin.,
Ref :-   Book : Martindale    Page : 523,542   Edition : 38,


►  Contraindication : hydantoin hypersensitivity, Sinus bradycardia, Stokes- Adams syndrome, SA node block, second or third degree AV block,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 236   Edition : 3,
  ►  Mechanism of Action :   Fosphenytoin is converted into phenytoin by phosphatases in liver and blood cells, phenytoin alters Na, K and Ca conductance, membrane potential and the concentration of amino acids and the Neurotransmitters NE, ACH and GABA.The major action of Phenytoin is to block sodium channels and inhibits the generation of rapidly repetitive action potentials,
Ref :-   Book : Goodman    Page : 592   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Valerin with Another pathway,

  ►  Pathway with its reference as follows :-
  • Valeremic acid have Anticonvulsant activity --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Long-term develop below normal blood levels of calcium , which may be related to drug -induced vitamin -D deficiency. ., VITAMIN A with Long-term lowered blood level of vitamin A .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   8 min,    Max value :-   15 min,
    Ref :-   Book : Goodman    Page : 592   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   About 30 minutes after i.m injection,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 523   Edition : 38,