Fosphenytoin is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 525   Edition : 525,

  ►   Brandname : Cerebyx

  ►  Strength : Injection with 75  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 525   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tonic-clonic status epilepticus IV infusion 15 mg/kg Injection It's the loading dose in PSE; as a single dose at a rate of 100 to 150 mg/minute.
2 Seizures i.m or i.v 10 15 mg/kg Injection For seizures other than in status epilepticus; It's the loading dose; as a single dose at a rate of 50 to 100 mg/minute.
3 Seizures IV 10 15 mg/kg Injection For treatment or prophylaxis of seizures other than in status epilepticus, loading dose in PSE given as a single dose at a rate of 1 to 2 mg/kg per minute.

Ref :-  Book : Martindale    Page : 525   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tonic-clonic status epilepticus IV infusion 15 mg/kg Injection

Ref :- Book : Martindale    Page : 525   Edition : 37,
►  Side Effect : behavioural changes, cardiac arrhythmia, gingival hyperplasia, glycosuria, Hirsutism, hyperglycemia, megaloblastic anaemia, osteomalacia, Severe cardiovascular reaction, Stevens-Johnson syndrome, toxic epidermal necrolysis, increased frequency of seizures,
Ref :-   Book : Goodman    Page : 592   Edition : 12,

►  Drug Interaction : Drug interaction of Fosphenytoin is with Warfarin , liraglutide , Carbamazapine , Lidocaine ,
Ref :-   Book : Martindale    Page : 539   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  A potentially more serious type of interaction may occur because Fosphenytoin metabolism is saturable: toxic concentrations of Fosphenytoin can develop in patients given drugs that inhibit Fosphenytoin metabolism even to quite a minor degree. Fosphenytoin itself is also a potent enzyme inducer, and induces the metabolism of a number of drugs, including some antibacterials, anticoagulants, corticosteroids, quinidine, and sex hormones (notably, oral contraceptives). The hypotensive properties of dopamine and the cardiac depressant properties of drugs such as lidocaine may be dangerously enhanced by intravenousFosphenytoin,
Ref :-   Book : Martindale    Page : 542   Edition : 37,


►  Contraindication : severs SA, AV, or intraventricular block, Sinus bradycardia, Stokes- Adams syndrome,
Ref :-   Book : Martindale    Page : 524   Edition : 37,
  ►  Mechanism of Action :   Fosphenytoin is converted into phenytoin by phosphatases in liver and blood cells, phenytoin alters Na, K and Ca conductance, membrane potential and the concentration of amino acids and the Neurotransmitters NE, ACH and GABA.The major action of Phenytoin is to block sodium channels and inhibits the generation of rapidly repetitive action potentials,
Ref :-   Book : Goodman    Page : 592   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Valerin with Another pathway,

  ►  Pathway with its reference as follows :-
  • Valeremic acid have Anticonvulsant activity --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Long-term develop below normal blood levels of calcium , which may be related to drug -induced vitamin -D deficiency. ., VITAMIN A with Long-term lowered blood level of vitamin A .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   0.13 hours,    Max value :-   0.25 hours,
    Ref :-   Book : Goodman    Page : 592   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,