Fospropofol is a Medicine belongs to General anaesthetics group whose information about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12,

  ►   Brandname : Lusedra

  ►  Strength : Injection with 35  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 336   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1940   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Given for sedation in adult patients undergoing diagnostic or therapeutic procedures IV bolus Injection In those aged under 65 years, and who are healthy or have mild systemic disease, an initial bolus injection of 6.5 mg/kg (minimum: 385 mg, maximum: 577.5 mg) may be followed by supplemental doses of 1.6 mg/kg (minimum: 105 mg, maximum: 140 mg) given no more frequently than every 4 minutes. Patients aged 65 years and older, or those with severe systemic disease, should be given 75% of the usual initial (minimum: 297.5 mg, maximum: 437.5 mg) and supplemental (minimum: 70 mg, maximum: 105 mg) doses.

Ref :-  Book : Martindale    Page : 1902   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : respiratory depression, Anaphylactoid reactions, propofol infusion syndrome, fever, Pancreatitis, decrease in blood pressure,
Ref :-   Book : Martindale    Page : 1947   Edition : 37,

►  Drug Interaction : Drug interaction of Fospropofol is with CNS depressants, Opiods, ,  Atracurium , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) ,
Ref :-   Book : Martindale    Page : 1902,1912   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The use of propofol with other CNS depressants, including those used in premedication, may increase the sedative, anaesthetic, and cardiorespiratory depressant effects of propofol. It is recommended that propofol is given after opioids so that the dose of propofol can be carefully titrated against the response. The dosage of propofol should be reduced if used with nitrous oxide or halogenated anaesthetics. Although propofol does not potentiate the effects of neuromuscular blockers, bradycardia and asystole have occurred after use of propofol with atracurium or suxamethonium.,
Ref :-   Book : Martindale    Page : 1902,1912   Edition : 38,


►  Contraindication : , patients known to be allergic to it, who have peanut, soya, or egg allergy, Children aged 16 years or less should not be used to provide continuous sedation for ventilated patients under intensive care, not recommended for use in obstetrics including caesarean section,
Ref :-   Book :    Page :    Edition : , Martindale    Page : 1902,1912   Edition : 38,
  ►  Mechanism of Action :   Fospropofol is a prodrug of propofol. The sedation and hypnotic actions are mediated by its action on GABAA receptors; agonism at these receptors results in an increased chloride conduction and hyperpolarization of neurons.,
Ref :-   Book : Goodman    Page : 537   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • Sedative effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Goodman    Page : 537   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   t1/2 for hydrolysis is 8 min, and a terminal t1/2 ~46 min.,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 537   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA