Furosemide is a Medicine belongs to Diuretics group whose information about Brand can be referenced from   Book : Martindale    Page : 1425   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Frusemix,Frusenex,Frusix,Lasix,Froop,Frusid,Frusol,fruselac,lasilactone

  ►  Strength : Tablet with 20  mg, Tablet with 40  mg, Tablet with 80  mg, Oral solution with 8  mg/ml, Oral solution with 10  mg/ml, Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Basic & Clinical pharmacology    Page : 262   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 40 mg Tablet o.d. Some patients may need doses of 80 mg or more daily given as one or two doses daily, or intermittently. Severe cases may require gradual titration of the furosemide dosage up to 600 mg daily. In an emergency or when oral therapy cannot be given, 20 to 50 mg of furosemide may be given by slow i.v injection.
2 Pulmonary oedema slow i.v 40 mg Injection If an initial slow i.v injection of 40 mg does not produce a satisfactory response within one hour, a further 80 mg may be given slowly i.v.
3 Oliguria in acute or chronic renal failure IV infusion 250 500 mg Injection Given when the glomerular filtration rate is less than 20 mL/minute but greater than 5 mL/minute (furosemide 250 mg diluted to 250 mL in a suitable diluent) and infused over one hour.
4 Chronic renal impairment Oral 250 mg May be increased, if necessary in steps of 250 mg every 4 to 6 hours to a maximum of 1.5 g in 24 hours.
5 hypertension Oral 40 80 mg Tablet Above doses given daily, either alone, or with other antihypertensives.

Ref :-  Book : Martindale    Page : 1387   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oedema Oral 1 3 mg/kg Oral solution
2 Oliguria 12 Year 18 Year Oral 250 mg Oral solution
3 Oliguria 1 Month 12 Year IV infusion 2-5 mg/kg Injection
4 Oliguria 12 Year 18 Year IV infusion 250 mg Injection

Ref :- Book : Martindale    Page : 1387   Edition : 38,
Precaution :- If a Patient is using 'Furosemide' drug in  Severe Pre-Eclampsia  disease, then Please contra:hypokalemia .

Precaution :- If a Patient is using 'Furosemide' drug in  Eclampsia with pulmonary oedema  disease, then Please Contraindication: Hypokalemia .

Precaution :- If a Patient is using 'Furosemide' drug in chronic kidney disease disease, then Please Should not be used   if he ever suffered from PERICARDIAL EFFUSION disease.
Precaution :- If a Patient is using 'Furosemide' drug in heart failure disease, then Please Use with potassium sparing diuretics   if he ever suffered from hypokalemia disease.
Precaution :- If a Patient is using 'Furosemide' drug in  bartter syndrome  disease, then Please avoid thiazide diuretics. .

Precaution :- If a Patient is using 'Furosemide' drug in  Acute Pancreatitis  disease, then Please use with caution .

►  Side Effect : Common adverse effects:, volume contraction alkalosis, headache, muscle cramp, Blurred Vision, hypokalaemia, ototoxicity, hyperuricaemia, hypomagnesemia, dyspepsia, glycosuria, Serious adverse effects are, erythema multiforme, Stevens-Johnson syndrome, Pancreatitis, aplastic or haemolytic anaemia, leucopenia, thrombocytopenia, hypotension,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 351   Edition : 3,

►  Drug Interaction : Drug interaction of Furosemide is with Amiloride , Cefalotin, Paracetamol , Nateglinide , Aliskiren Fumarate , Phenytoin , Metolazone , Felbamate, Norgestrel , Ropivacaine , Probenecid , Oxcarbazepine , Theophylline ,
Ref :-   Book : Martindale    Page : 1423   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Furosemide may enhance the nephrotoxicity of cephalosporin antibacterials such as cefalotin and can enhance the ototoxicity of aminoglycoside antibacterials and other ototoxic drugs. Severe electrolyte disturbances may occur in patients given metolazone with furosemide. NSAIDs may antagonise the diuretic effect of furosemide and other diuretics.,
Ref :-   Book : Martindale    Page : 1423   Edition : 37,


►  Contraindication : hypersensitivity to sulfonamides, Anuria, co-administration with aminoglycosides increases ototoxicity and nephrotoxicity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 351   Edition : 3,
  ►  Mechanism of Action :   Inhibit sodium reabsorption by reversibly and competitively inhibiting sodium-potassium-chloride co-transporter NKCC2 in apical (luminal) membrane of cells in thick ascending limb of loop of Henle; also reduce or abolish the lumen-positive transepithelial potential difference.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 351   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cranberry with Another pathway, beetroot with same pathway, Horsetail with Another pathway,

  ►  Pathway with its reference as follows :-
  • High water content, potassium --- (Duck, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). America: CRC. )
  • High water content --- ( Coles, L. & Clifton, P. (2012). Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial. Nutrition Journal, 11(1). http://dx.doi.org/10.1186/1475-2891-11-106 )
  • Diuretic properties --- (R.V, G. (2010). Nature’s Weapon against Urinary Tract Infections. International Journl OF Drug Development And Research, 3(3). )

  •   ►  URL -- https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PA822&dq=Hand+Book+Of+Medicinal+Herbs+(2nd+ed.)&hl=en&sa=X&redir_esc=y#v=onepage&q=Hand%20Book%20Of%20Medicinal%20Herbs%20(2nd%20ed.)&f=false, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545899/, http://www.ijddr.in/drug-development/natures-weapon-against-urinary-tract-infections.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ALOE VERA with Cause hypokalemia with potassium depleting diuretic ., POTASSIUM with Increases urinary mineral excretion., MANGANESE with Increases urinary mineral excretion.,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf , http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, Biliary,
    Ref :-   Book : Martindale    Page : 1423   Edition : 37,


    ►    Plasma Half-life :   Min value :-   Up to about 2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1390   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA