Fusidic acid is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 303   Edition : 38,

  ►   Brandname : Fucin,Fucinex,Fucidin,Fucithalmic,Fucidine

  ►  Strength : Tablet with   , Ointment with   , Suspension with   , Injection with   , Cream with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 302   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, Oral, IV,
Reference :-   Book : Martindale    Page : 302   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cutaneous staphylococcal infection Oral 250 mg Tablet b.d.
2 Cutaneous staphylococcal infection Oral 750 mg Suspension t.i.d. It is the usual dose.
3 Staphylococcal infections Slow IV infusion 500 mg Injection t.i.d. i.e in case of severe infection; given (as Sodium fusidate) for those weighing over 50 kg.
4 Staphylococcal infections Slow IV infusion 6 7 mg/kg Injection t.i.d. i.e in case of severe infection; given (as Sodium fusidate) for those weighing less than 50 kg.
5 Staphylococcal infections Topical For local skin infection; Sodium fusidate is given as 2% ointment, or medicated dressing, cream or gel. And Eye drops containing fusidic acid 1% are used in eye infections.

Ref :-  Book : Martindale    Page : 302   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Penicillin-resistant staphyloccal infection up to 1 Year Oral 16 mg/kg Suspension t.i.d.
2 Penicillin-resistant staphyloccal infection 1 Year 5 Year Oral 250 mg Suspension t.i.d.
3 Penicillin-resistant staphyloccal infection 5 Year 12 Year Oral 500 mg Suspension t.i.d.
4 Penicillin-resistant staphyloccal infection 1 month above 1 month less than 50 kg IV infusion 6 7 mg/kg Injection t.i.d.

Ref :- Book : Martindale    Page : 302   Edition : 38,
►  Organ Affected Liver Disease – (Excretion reduced)  

►  Side Effect : Venospasm, thrombophlebitis, and haemolysis have occurred in patients given i.v doses, Hypocalcaemia has occurred after use of i.v doses above those recommended, Rashes, and irritation may occur with topical fusidates, ,
Ref :-   Book : Martindale    Page : 302   Edition : 38,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Fusidic acid is with NA

  ►    Mechanism of Drug Drug Interaction :  Although the exact metabolic pathways of fusidic acid are not known, an interaction has been suspected with drugs metabolised by the hepatic cytochrome P450 isoenzyme CYP3A4 and UK licensed product information suggests avoiding their use with fusidic acid.,
Ref :-   Book : Martindale    Page : 302   Edition : 38,


►  Absolute Contraindication : Intramuscular or subcutaneous use may lead to tissue necrosis.  

►  Contraindication : Intramuscular or subcutaneous use,
Ref :-   Book : Martindale    Page : 302   Edition : 38,
  ►  Mechanism of Action :   Fusidic acid is a steroidal antibacterial with a bacteriostatic or bactericidal activity, mainly against Gram-positive bacteria. It inhibits bacterial protein synthesis, it does not bind to the bacterial ribosome, but inhibits a factor necessary for translocation of peptide subunits and elongation of peptide chain. ,
Ref :-   Book : Martindale    Page : 302   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Fecal,
Ref :-   Book : Martindale    Page : 303   Edition : 38,


►    Plasma Half-life :
  Min value :-   10 hours,    Max value :-   15 hours,
Ref :-   Book : Martindale    Page : 303   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   Mean plasma conc.; 2 ,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 303   Edition : 38,