Fusidic acid is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 305   Edition : 37,

  ►   Brandname : Fusibact,Fusiwal,Fucidin,Fucithalmic

  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, Oral, IV,
Reference :-   Book : Martindale    Page : 302   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cutaneous staphylococcal infection Oral 250 mg Tablet b.d.
2 Cutaneous staphylococcal infection Oral 750 mg Suspension t.i.d.
3 Staphylococcal infections Slow IV infusion 500 mg Injection t.i.d. In severe infection; for those weighing over 50 kg.
4 Staphylococcal infections Slow IV infusion 6 7 mg/kg Injection t.i.d. In severe infection; for those weighing less than 50 kg.
5 Staphylococcal infections Topical 2 % For skin infection; Given as ointment, medicated dressing, cream or gel.
6 Staphylococcal infections Topical 1 % Eye Drop For eye infection.

Ref :-  Book : Martindale    Page : 304,305   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Penicillin-resistant staphyloccal infection >1 Day 1 Year Oral 16 mg/kg Suspension t.i.d.
2 Penicillin-resistant staphyloccal infection 1 Year 5 Year Oral 250 mg Suspension t.i.d.
3 Penicillin-resistant staphyloccal infection 5 Year 12 Year Oral 500 mg Suspension t.i.d.
4 Penicillin-resistant staphyloccal infection 1 Month <1 Month >50 IV infusion 6 7 mg/kg Injection t.i.d.

Ref :- Book : Martindale    Page : 302   Edition : 38,
►  Organ Affected Liver Disease – (Excretion reduced)  

►  Side Effect : Venospasm, thrombophlebitis, haemolysis, hypocalcaemia, Rashes, Irritation, jaundice, changes in liver function,
Ref :-   Book : Martindale    Page : 302   Edition : 38,

►  Drug Interaction : Drug interaction of Fusidic acid is with Ritonavir, Saquinavir, Stavudine,
Ref :-   Book : Martindale    Page : 302   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  An interaction has been suspected with drugs metabolised by the hepatic cytochrome P450 isoenzyme CYP3A4. ,
Ref :-   Book : Martindale    Page : 302   Edition : 37,


►  Absolute Contraindication : Intramuscular or subcutaneous use may lead to tissue necrosis.  

►  Contraindication : kernicterus,
Ref :-   Book : Martindale    Page : 302   Edition : 38,
  ►  Mechanism of Action :   Fusidic acid is a steroidal antibacterial with a bacteriostatic or bactericidal activity, mainly against Gram-positive bacteria. It inhibits bacterial protein synthesis, it does not bind to the bacterial ribosome, but inhibits a factor necessary for translocation of peptide subunits and elongation of peptide chain. ,
Ref :-   Book : Martindale    Page : 302   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary,
Ref :-   Book : Martindale    Page : 303   Edition : 38,


►    Plasma Half-life :
  Min value :-   10 hours,    Max value :-   15 hours,
Ref :-   Book : Martindale    Page : 303   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 303   Edition : 38,