Ganciclovir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 984   Edition : 38,

  ►   Brandname : Cymevene,Virgan,Cytovene; Ganguard; Gavir

  ►  Strength : Capsule with 250  mg, Capsule with 500  mg, Injection with 500  mg/vial, Intraocular implant with 4.5  mg ganciclovir/implant,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12, Basic & Clinical pharmacology    Page : 889   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion, Topical,
Reference :-   Book : Martindale    Page : 983   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 CMV infection IV infusion 5 mg/kg Injection b.d. For 14 to 21 days, This induction period may be followed by maintenance therapy to prevent recurrence or progression of the disease. The usual maintenance dosage is 5 mg/kg by intravenous infusion as a single daily dose for 7 days each week or 6 mg/kg daily for 5 days each week.
2 CMV infection IV infusion 5 mg/kg Injection b.d. In immunocompromised patients for 7 to 14 days.
3 Acute Herpes simplex keratitis Topical Gel 0.15% Applied 5 times daily untill corneal healing occurs, than 3 times daily for the further 7 days.

Ref :-  Book : Martindale    Page : 982   Edition : 38, Martindale    Page : 983   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 CMV infection IV infusion 6 mg/kg Injection b.d.

Ref :- Book : Martindale    Page : 983   Edition : 38,
Precaution :- If a Patient is using 'Ganciclovir' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

►  Side Effect : neutropenia, thrombocytopenia, anaemia, dyspnoea, headache, fever, rash, pruritus, asthenia, gastrointestinal disturbance, infections, increases in serum creatinine, abnormal liver fuction tests, anaphylaxis, arrhythmia, hypotension, Pancreatitis, haematuria, When given intravenously, irritation or phlebitis may occur at the site of injection,
Ref :-   Book : Martindale    Page : 983   Edition : 38,

►  Drug Interaction : Drug interaction of Ganciclovir is with , Antineoplastic , , ,  Probenecid , Mycophenolate mofetil , Amphotericin B , Dapsone , Flucytosine , Hydroxycarbamide (Hydroxyurea), Pentamidine , Imipenem ,
Ref :-   Book : Martindale    Page : 984   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid and other drugs that inhibit renal tubular secretion and resorption may reduce the renal clearance of ganciclovir, and so increase its serum concentrations. Use of intravenous ganciclovirwith oral mycophenolate mofetil may result in increased plasma concentrations of both drugs due to competition for renal tubular secretion. Drugs that inhibit rapid cell division such as amphotericin B, some antineoplastic drugs, co-trimoxazole, dapsone, flucytosine, hydroxycarbamide, nucleoside analogues, and pentamidine may have additive toxic effects if given with ganciclovir. Convulsions have been reported when ganciclovir was given with imipenem. ,
Ref :-   Book : Martindale    Page : 984   Edition : 38,


►  Contraindication : pregnancy, renal impairment, contact with the skin and eyes should be avoided,
Ref :-   Book : Martindale    Page : 984   Edition : 38,
  ►  Mechanism of Action :   Ganciclovir triphosphate inhibits CMV DNA polymerase more potently than it does cellular DNA polymerases.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 658   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • antiviral effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 984   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   2.5,    Max value :-   4.5 hours,
    Ref :-   Book : Martindale    Page : 984   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA