Gatifloxacin is a Medicine belongs to Antibacterial/ Fluoroquinolones group whose information about Brand can be referenced from   Book : Martindale    Page : 304   Edition : 38,

  ►   Brandname : Biogat,Gaticin,Gatiquin,Gatt,Zyquin,Zymaxid,Zymar

  ►  Strength : Eye Drop with 0.3 or 0.5  %, Solution with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 303   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, Oral, IV infusion,
Reference :-   Book : Martindale    Page : 303   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Susceptible infections Oral / i.v 2 mg/ml Solution Over 60 minutes.
2 Susceptible infections Oral 400 mg o.d.
3 Bacterial conjunctivitis Topical Eye Drop 0.3 or 0.5 %.

Ref :-  Book : Martindale    Page : 303   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Typhoid fever Oral 10 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 958   Edition : 19,
Precaution :- If a Patient is using 'Gatifloxacin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : cartilage damage, tendon rupture, peripheral neuropathy, increased intracranial pressure, seizure, hypersensitivity reactions, rash, gastrointestinal disturbance,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,

►  Drug Interaction : Drug interaction of Gatifloxacin is with NA

  ►    Mechanism of Drug Drug Interaction :  Use of gatifloxacin with drugs that alter blood-glucose concentrations increases the risk of blood-glucose disturbances.,
Ref :-   Book : Martindale    Page : 304   Edition : 38,


►  Contraindication : hypersensitivity reactions to quinolones, diabetic patient,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3, Martindale    Page : 303   Edition : 38,
  ►  Mechanism of Action :   Inhibit bacterial type II topoisomerases. At therapeutic concentrations, quinolones have a bacterial effect by causing dissociation of the topoisomerase from cleaved DNA, leading to double-stranded DNA.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Eyebright with Another pathway,

  ►  Pathway with its reference as follows :-
  • have Anti-infective activity --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 304   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   7 ,    Max value :-   14 hours,
    Ref :-   Book : Martindale    Page : 304   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 ,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 304   Edition : 38,