Gemcitabine hydrochloride is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 802   Edition : 38,

  ►   Brandname : Abingem; Gemzar,Biogem,Gemzar,Gemcite,Oncogem

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 802   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 801   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pancreatic cancer IV 1 gm/m2 Injection Once weekly For up to 7 weeks.
2 Non-small cell lung cancer IV 1 gm/m2 Injection Once weekly For 3 consecutive weeks out of 4 is recommended.
3 Bladder cancer IV 1 gm/m2 Injection On days 1, 8, and 15 of a 28-day cycle.
4 Breast cancer IV 1.25 gm/m2 Injection Given on days 1 and 8 of a 21-day cycle.
5 Ovarian cancers IV 1 gm/m2 Injection On days 1 and 8 of a 21-day cycle.

Ref :-  Book : Martindale    Page : 801   Edition : 38, Martindale    Page : 801   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : bone marrow depression, mild to moderate severity. Rashes, often associated with pruritus, and flulike symptoms, Gastrointestinal disturbances occur, especially nausea and vomiting, haematuria, proteinuria, transient liver enzyme elevations, and serious hepatotoxicity, including liver failure and death, ,
Ref :-   Book : Martindale    Page : 801   Edition : 38, Martindale    Page : 802   Edition : 38,

►  Drug Interaction : Drug interaction of Gemcitabine hydrochloride is with Paclitaxel, Etoposide,
Ref :-   Book : Martindale    Page : 802   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The use of paclitaxel before gemcitabine caused a decrease in the systemic clearance, volume of distribution, and interpatient pharmacokinetic variability of gemcitabine. Etoposide was stopped because of unexpected pulmonary toxicity.,
Ref :-   Book : Martindale    Page : 802   Edition : 38,


►  Contraindication : pulmonary toxicity, hepatic impairment, renal impairment, microangiopathic haemolytic anaemia.,
Ref :-   Book : Martindale    Page : 801   Edition : 38, Martindale    Page : 802   Edition : 38,
  ►  Mechanism of Action :   Gemcitabine is an analogue of cytarabine that is metabolised intracellularly to active diphosphate and triphosphate nucleosides, which inhibit DNA synthesis and induce apoptosis. It is primarily active against cells in S phase,
Ref :-   Book : Martindale    Page : 801   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Faecal, Renal,
    Ref :-   Book : Martindale    Page : 802   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   42 ,    Max value :-   94 minutes,
    Ref :-   Book : Martindale    Page : 802   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA