Gemfibrozil is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1391   Edition : 38,

  ►   Brandname : Lopid; Gempar; Lipizyl,Normolip

  ►  Strength : Tablet with 600  mg, Capsule with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12, Martindale    Page : 1391   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1391   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperlipidaemia Oral 1.2 gm Daily in 2 divided doses given 30 minutes before the morning and evening meals. Alternatively, a single daily dose of 900 mg has been given 30 minutes before the evening meal.

Ref :-  Book : Martindale    Page : 1391   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : anorexia, nausea, gastric discomfort, headache, Dizziness, vertigo, fatigue, Skin rashes, pruritus, photosensitivity, alopecia, impotence, anaemia, leucopenia, thrombocytopenia, Raised serum-aminotransferase concentrations, Elevated creatine phosphokinase concentrations, syndrome of myositis, myopathy, rhabdomyolysis,
Ref :-   Book : Martindale    Page : 1391,1324   Edition : 38,

►  Drug Interaction : Drug interaction of Gemfibrozil is with Bexarotene, Pioglitazone Hydrochloride , Rosiglitazone , Repaglinide ,
Ref :-   Book : Martindale    Page : 1391   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Gemfibrozil is an inhibitor of a number of cytochrome P450 isoenzymes, including CYP2C8, CYP2C9, CYP2C19, and CYP1A2 and may increase the plasma concentration of drugs metabolised by these isoenzymes; it also inhibits some UDP-glucuronosyltransferases. Increased plasma concentration of bexarotene, pioglitazone and rosiglitazone have been reported with gemfibrozil, and use of gemfibrozil in patients receiving repaglinide is contra-indicated due to the risk of serious hypoglycaemia.,
Ref :-   Book : Martindale    Page : 1391   Edition : 38,


►  Contraindication : used with caution in renal impairment and is contra-indicated if creatinine clearance is below 15 mL/minute unless the patient is on dialysis, patients with severe hepatic impairment or significant liver disease, gallstones or gallbladder disorders, or hypoalbuminaemic states such as nephrotic syndrome.,
Ref :-   Book : Martindale    Page : 1391,1324   Edition : 38,
  ►  Mechanism of Action :   Effects of Gemfibrozil on blood lipids are mediated by their interaction with peroxisome proliferator-activated receptors (PPARs) , which regulate gene transcription. Three PPAR isotypes have been identified. Gemfibrozil bind to PPAR, which is expressed primarily in the liver and brown adipose tissue and to a lesser extent in kidney, heart, and skeletal muscle. It reduce triglycerides through PPAR-mediated stimulation of fatty acid oxidation, increased LPL synthesis, and reduced expression of apoC-III. An increase in LPL would enhance the clearance of triglyceride-rich lipoproteins. A reduction in hepatic production of apoC-III, which serves as an inhibitor of lipolytic processing and receptor-mediated clearance, would enhance the clearance of VLDL. It -mediated increases in HDL-C are due to PPAR stimulation of apoA-I and apoA-II expression, which increases HDL levels.,
Ref :-   Book : Goodman    Page : 902   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- VITAMIN B12 with Reduces vitamin & mineral absorption ., BETACAROTENE with Reduces vitamin & mineral absorption ., IRON with Reduces vitamin & mineral absorption .,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1391   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1391   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 ,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1391   Edition : 38,