Gentamicin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 308   Edition : 38,

  ►   Brandname : Garamycin; Cidomycin; Bactigen,Genoptic,Gentacidin,Gentak,Gentasol,Ocu-Mycin

  ►  Strength : Injection with 10  mg/ml, Injection with 40  mg/ml, Eye Drop with   , Cream with   , Ophthalmic Solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 828   Edition : 12, Martindale    Page : 308   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, Topical, Oral, inhalation, intraventricular, intrathecal ,
Reference :-   Book : Martindale    Page : 305   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Infections IM 3 5 mg/kg Injection t.i.d.
2 Streptococcal endocarditis. parenteral 1 mg/kg Injection t.i.d.
3 Urinary-tract infections parenteral 160 mg Injection o.d.
4 Meningitis intrathecally or intraventricularly 1 5 mg Injection Daily with intramuscular therapy.
5 Skin infections Topical In concentrations of 0.1%,
6 Eyes and ears infection Topical Concentrations of 0.3%.
7 Dosing in Obesity: Critically ill patient, Give 7 mg/kg of Adjusted BW IV q24 h. Ref; The Sanford Guide To Antimicrobial Therapy, pg 231, ed 47.

Ref :-  Book : Martindale    Page : 305   Edition : 38, Martindale    Page : 179,305   Edition : 38,    Page :    Edition : ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 BACTERIAL MENINGITIS less than1 Day 7 Day 5 mg/kg
2 BACTERIAL MENINGITIS 8 Day 28 Day 7.5 mg/kg
3 BACTERIAL MENINGITIS 7.5 mg/kg
4 Pyelonephritis IV 3 5 mg/kg/day Injection
5 Endocarditis IM or IV 3 mg/kg/day Injection
6 Brucellosis more than and equal 8 Year i.v/i.m 3 5 mg/kg/day Injection
7 Osteomyelitis IV 3 5 mg/kg/day Injection

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2093    Edition : 19, Nelson's textbook of Pediatrics    Page : 2093    Edition : 19, Nelson's textbook of Pediatrics    Page : 1832    Edition : 19, Nelson's textbook of Pediatrics    Page : 1625    Edition : 19, Nelson's textbook of Pediatrics    Page : 981    Edition : 19,
Precaution :- If a Patient is using 'Gentamicin' drug in  acute kidney injury   disease, then Please be avoided .

►  Side Effect : neuromuscular-blocking action and respiratory depression and muscular paralysis, polyradiculitis, and ventriculitis after intrathecal, intracisternal, or intraventricular . Subconjunctival injection of gentamicin may lead to pain, hyperaemia, and conjunctival oedema., Hypersensitivity reactions after local use, blood dyscrasias, purpura, nausea and vomiting, stomatitis, and signs of liver dysfunction such as increased serum-aminotransferase values and increased serum-bilirubin concentrations,, encephalopathy, confusion, lethargy, hallucinations, convulsions, and mental depression, Atrophy or fat necrosis at injection sites, meningeal irritation, arachnoiditis, , Cumulative ototoxicity, hearing loss, Vestibular damage, Reversible nephrotoxicity, acute renal failure, Decreased glomerular filtration rate, Electrolyte disturbances (notably hypomagnesaemia, but also hypocalcaemia and hypokalaemia), ,
Ref :-   Book : Martindale    Page : 306   Edition : 38,

►  Drug Interaction : Drug interaction of Gentamicin is with AMINOGLYCOSIDES , Cephalosporin , General anaesthetics , Opoids, , , ,  Vancomycin , Cyclosporine , Cisplatin , Fludarabine, Etacrynic acid, Furosemide , Dimenhydrinate , Zalcitabine,
Ref :-   Book : Martindale    Page : 307   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Use of other nephrotoxic drugs including other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. The neuromuscular-blocking properties of aminoglycosides may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids. There is a theoretical possibility that the antibacterial effects of aminoglycosides could be reduced by bacteriostatic antibacterials, but such combinations have been used successfully in practice. Renal excretion of zalcitabine may be reduced by aminoglycosides. Gentamicin may inhibit α-galactosidase activity and should not be used with agalsidase alfa or beta. ,
Ref :-   Book : Martindale    Page : 307   Edition : 38,


►  Contraindication : Hypersensitivity to Gentamicin and other aminoglycosides, It should be avoided in patients with myasthenia gravis, and great care is required in patients with parkinsonism and other conditions characterised by muscular weakness.,
Ref :-   Book : Martindale    Page : 306   Edition : 38,
  ►  Mechanism of Action :   gentamicin bind to the 30S bacterial ribosomal subunit and disrupt the decoding of mRNA.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 566   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Cycloeudesmol have Antidiabetic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary,
    Ref :-   Book : Martindale    Page : 307   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   2,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 307   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   30,    Max value :-   60 min,
    Ref :-   Book : Martindale    Page : 307   Edition : 38,