Gliclazide is a Medicine belongs to Antidiabetic group whose information about Brand can be referenced from   Book : Martindale    Page : 473   Edition : 38,

  ►   Brandname : Diamicron,Glycigon,Glycinorm,Aviglic, Claz, Diazide, Dizide

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 473   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 473   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Type 2 diabetes mellitus Oral 40 mg 80 mg Tablet For elderly patients Daily given with breakfast, if necessary up to 320 mg daily.
2 Type 2 diabetes mellitus Oral 160 mg Tablet Daily given in 2 divided doses.

Ref :-  Book : Martindale    Page : 473   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Type 2 diabetes mellitus 12Year 18Year Oral 20 mg Tablet o.d.

Ref :- Book : Martindale    Page : 473    Edition : 38,
►  Side Effect : hypoglycemia, Rashes, diarrhea, nausea, Dizziness,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 538   Edition : 3,

►  Drug Interaction : Drug interaction of Gliclazide is with Angiotensin converting enzyme inhibitor, Alcohol, Salicylates, Coumarin Anticoagulant, FLUOROQUINOLONES , Monoamine Oxidase Inhibitor, Tricyclic antidepressant , Beta Blockers , Calcium Channel Blockers ,  Allopurinol , Azapropazone, Phenylbutazone, Fluconazole , Ketoconazole , Miconazole, Chloramphenicol , Cimetidine , Clofibrate, Heparin , Octreotide , Ranitidine , Sulfinpyrazone, Sulfonamide, Tetracycline ,
Ref :-   Book : Martindale    Page : 473,503   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  An increased hypoglycaemic effect has occurred or might be expected with ACE inhibitors, alcohol, allopurinol, some analgesics (notably azapropazone, phenylbutazone, and the salicylates), azole antifungals (fluconazole, ketoconazole, and miconazole), chloramphenicol, cimetidine, clofibrate and related compounds, coumarin anticoagulants, fluoroquinolones, heparin, MAOIs, octreotide (although this may also produce hyperglycaemia), ranitidine, sulfinpyrazone, sulfonamides (including co-trimoxazole), tetracyclines, and tricyclic antidepressants. Beta blockers have been reported both to increase hypoglycaemia and to mask the typical sympathetic warning signs. There are sporadic and conflicting reports of a possible interaction with calcium-channel blockers.Octreotide can inhibit sulfonylurea induced release of insulin from the pancreas. ,
Ref :-   Book : Martindale    Page : 473,503   Edition : 38,


►  Contraindication : diabetic ketoacidosis,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 538   Edition : 3,
  ►  Mechanism of Action :   Inhibit the β-cell K+/ATP channel at the SUR1 subunit, thereby stimulating insulin release from pancreatic β-cell and increasing circulating insulin to levels sufficient to overcome insulin resistance.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 538   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with Another pathway,

  ►  Pathway with its reference as follows :-
  • quercetin have antidiabetic effect --- ( C, ,. (2011). Anti-diabetic effects of Allium cepa (onions) aqueous extracts on alloxan-induced diabetic Rattus novergicus. Journal Of Medicinal Plants Research, 5(1996-0875), 1134-1139,. )

  •   ►  URL -- http://www.academicjournals.org/article/article1380531959_Ozougwu.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 473   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   10 hours,    Max value :-   12 hours,
    Ref :-   Book : Martindale    Page : 473   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA