Glucagon is a Medicine belongs to Endocrine drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1555   Edition : 38,

  ►   Brandname : GlucaGen

  ►  Strength : Injection with 1  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, SC,
Reference :-   Book : Martindale    Page : 1554   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe hypoglycaemic reactions s.c, i.v, i.m 1 mg Injection When the patient cannot take glucose by mouth and intravenous glucose is not feasible.
2 Diagnostic aid in gastrointestinal examinations IM 1mg 2 mg Injection An onset of action of 4 to 15 minutes and a duration of effect of 10 to 40 minutes; 0.2 to 2 mg intravenously produces an effect within 1 minute that lasts for 5 to 25 minutes.
3 Relaxation of the stomach duodenum and small bowel IV 200 500 micrograms Injection
4 Relaxation of the stomach duodenum and small bowel IM 1 mg Injection
5 Relax the colon IV 500 microgram 750 Microgram Injection
6 Relax the colon IM 1 mg 2 mg Injection

Ref :-  Book : Martindale    Page : 1554   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe hypoglycaemia associated with diabetes younger than 6 Year 8 Year Less than 25 kg s.c, i.v, i.m 500 micrograms Injection
2 Endogenous hyperinsulinaemia 1 Month 2 Year IM or IV 1 mg Injection
3 Endogenous hyperinsulinaemia IM or IV 200 micrograms/kg (maximum 1 mg) Injection

Ref :- Book : Martindale    Page : 1554   Edition : 38,
►  Side Effect : hypersensitivity reactions, abdominal pain, hypotension, tachycardia, hypokalaemia, nausea, vomiting, Hypersensitivity reactions( including rash and anaphylactic shock), bradycardia, hypertension,
Ref :-   Book : Martindale    Page : 1554   Edition : 38,

►  Drug Interaction : Drug interaction of Glucagon is with Beta Blockers , Antimuscarinic,  Indomethacin ,
Ref :-   Book : Martindale    Page : 1555   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Beta blocker and indometacin may also reduce glucagon ‘s hyperglycaemic effect.Glucagon inhibits gastrointestinal motility and an additive effect may be seen with antimuscarinic drugs.,
Ref :-   Book : Martindale    Page : 1555   Edition : 38,


►  Contraindication : phaeochromocytoma, Caution is also required when it is being used as a diagnostic aid in diabetic patients or in elderly patients with heart disease,
Ref :-   Book : Martindale    Page : 1554   Edition : 38, Martindale    Page : 1555   Edition : 38,
  ►  Mechanism of Action :   Glucagon is an endogenous polypeptide hormone that is produced by the alpha cells of the pancreatic islets of Langerhans. It is a hyperglycaemic that mobilises glucose by activating hepatic glycogenolysis. ,
Ref :-   Book : Martindale    Page : 1554   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fenugreek seed with Another pathway, Blue Berries with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antidiabetic effect . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Anthocyanins which have the ability to stimulate insulin secretation --- ( Jayaprakasam, B., Vareed, S., Olson, L., & Nair, M. (2005). Insulin Secretion by Bioactive Anthocyanins and Anthocyanidins Present in Fruits. J. Agric. Food Chem., 53(1), 28-31. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://www.ncbi.nlm.nih.gov/pubmed/15631504,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1555   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   3,    Max value :-   6 min,
    Ref :-   Book : Martindale    Page : 1555   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA