Glyceryl trinitrate (nitroglycerin) is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1394   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Nitrostat, Nitrotransdermal, Minitran, Nitrodisc, NitroBid, Angispan-TR, Glynit,Angistat,Nitrolong Tablet

  ►  Strength : Tablet with 0.3  mg, Tablet with 0.4  mg, Tablet with 0.6  mg, Capsule with 2.5  mg, Capsule with 6.5  mg, Capsule with 9  mg, Injection with 5  mg/ml, Ointment with 20  mg/ml, Transdermal Patch with   , Topical ointment with   , Sublingual spray with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12, Martindale    Page : 1395   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion, Topical, Intra-anally,
Reference :-   Book : Martindale    Page : 1392   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute angina Oral 300 600 micrograms Tablet
2 Acute angina Topical 400 micrograms Spray One or two sprays.
3 Stable angina pectoris Oral 2 5 mg Tablet t.i.d.
4 Unstable angina IV infusion 5 10 micrograms/minute Injection
5 Heart failure IV 5 25 micrograms/minute Injection
6 Acute myocardial infarction IV 5 25 micrograms/minute Injection
7 Phlebitis and extravasation Topical 5 mg Transdermal Patch Applied distal to the intravenous site; the patch should be replaced at a different skin site either daily or after 3 to 4 days.
8 unstable angina Oral upto 5 mg Tablet
9 Heart failure Oral 5 mg Tablet Dose: Repeated as needed until symptom are controlled.
10 Chronic ANAL FISSURE rectal 0.4 % Ointment
11 Stable angina pectoris Oral 2.5 6.5 mg Capsule t.i.d/q.i.d Increased up to 26 mg four times daily.

Ref :-  Book : Martindale    Page : 1392   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Vasodilation IV infusion 200 500 nanograms/kg per minute Injection
2 Anal fissure Topical 0.05 0.1 % Ointment

Ref :- Book : Martindale    Page : 1392   Edition : 38,
►  Side Effect : Dizziness, tachycardia, throbbing headache, vomiting, Restlessness, Blurred Vision, hypotension, syncope, impairment of respiration, bradycardia, local irritation, erythema, flushing of the face, , Localised burning sensation ,
Ref :-   Book : Martindale    Page : 1393   Edition : 38,

►  Drug Interaction : Drug interaction of Glyceryl trinitrate (nitroglycerin) is with , , VASODILATORS , Alcohol,  NA

  ►    Mechanism of Drug Drug Interaction :  The hypotensive effects of glyceryl trinitrate may be enhanced by alcohol, and by vasodilators and other drugs with hypotensive actions. The efficacy of sublingual and buccal tablet preparations may be reduced by drugs that cause dry mouth since dissolution may be delayed.,
Ref :-   Book : Martindale    Page : 1427   Edition : 37,


►  Contraindication : Should not be used in patients with severe hypotension, hypovolaemia, marked anaemia, heart failure . Angle-closure glaucoma used with caution in patients with severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. ,
Ref :-   Book : Martindale    Page : 1394   Edition : 38,
  ►  Mechanism of Action :   Nitrate and nitroprusside: Donate NO, which activates guanylyl cyclase and decreases dephosphorylation of myosin light chain in vascular smooth muscle, causing vasodilation .inhaled nitric oxide gas: selectively dilate the pulmonary vasculature.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 368   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Beet with same compound, Beet with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vasodilator --- (Duck, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). America: CRC. )
  • antianginal effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PA822&dq=Hand+Book+Of+Medicinal+Herbs+(2nd+ed.)&hl=en&sa=X&redir_esc=y#v=onepage&q=Hand%20Book%20Of%20Medicinal%20Herbs%20(2nd%20ed.)&f=false, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1394   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   1,    Max value :-   3 hours,
    Ref :-   Book : Goodman    Page : 751   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   with in 4 minutes,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 751   Edition : 12,