Gonadorelin is a Medicine belongs to sex hormone group whose information about Brand can be referenced from   Book : Martindale    Page : 2282   Edition : 38,

  ►   Brandname : HRF,Factrel

  ►  Strength : Injection with 100, 500  mcg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, IV, Oral, IM, intranasal, rectal,
Reference :-   Book : Martindale    Page : 2280   Edition : 38, Martindale    Page : 2282   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Diagnosis of hypothalamic- pituitary-gonadal dysfunction. s.c or i.v 100 micrograms Injection
2 Amenorrhoea s.c or i.v 5 20 micrograms Injection Over one minute every 90 minutes for up to 6 months.
3 Infertility s.c or i.v 5 20 micrograms Injection Over one minute every 90 minutes for up to 6 months.

Ref :-  Book : Martindale    Page : 2280   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Diagnosis of hypothalamic-pituitary-gonadal dysfunction 1 Year 18 Year s.c or i.v 2.5 micrograms/kg Injection

Ref :- Book : Martindale    Page : 2281   Edition : 38,
►  Side Effect : nausea, abdominal pain, abdominal discomfort, hormonal milieu, mood changes, Nervousness, palpitation, acne, dry skin, changes in scalp and body hair, alterations in liver function tests , alterations in blood lipids, decrease in glucose tolerance, arthralgia, paraesthesia, thrombophlebitis, swelling, pruritus, hypersensitivity reactions, bronchospasm, anaphylaxis, vaginal bleeding,
Ref :-   Book : Martindale    Page : 2282   Edition : 38,

►  Drug Interaction : Drug interaction of Gonadorelin is with , sex hormone ,  Spironolactone , Digoxin , Dopamine , Phenothiazine, Levodopa ,
Ref :-   Book : Martindale    Page : 2282   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs affecting pituitary secretion of gonadotrophins may alter the response to gonadorelin or its analogues; other hormonal therapy and corticosteroids can affect the response. Spironolactone and levodopa can stimulate gonadotrophins while phenothiazines, dopamine antagonists, digoxin, and sex hormones can inhibit gonadotrophin secretion ,
Ref :-   Book : Martindale    Page : 2282   Edition : 38,


►  Contraindication : in patients with pituitary adenoma as haemorrhagic infarction (pituitary apoplexy), should be stopped if the patient becomes pregnant.,
Ref :-   Book : Martindale    Page : 2282   Edition : 38,
  ►  Mechanism of Action :   Continuous administration: inhibit LH and FSH release; pulsatile administration: stimulate LH and FSH release. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 479   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 2282   Edition : 38,


►    Plasma Half-life :
  Min value :-   10,    Max value :-   40 minutes,
Ref :-   Book : Martindale    Page : 2282   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA