Gonadorelin is a Medicine belongs to sex hormone group whose information about Brand can be referenced from   Book : Martindale    Page : 2282   Edition : 38  

  ►   Brandname : HRF, Factrel
  ►  Strength : Injection with 100, 500 mcg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, IV, Oral, IM, intranasal, rectal
Reference :-   Book : Martindale    Page : 2280   Edition : 38   Martindale    Page : 2282   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Diagnosis of hypothalamic- pituitary-gonadal dysfunction. s.c or i.v 100 micrograms Injection
2 Amenorrhoea s.c or i.v 5 20 micrograms Injection Over one minute every 90 minutes for up to 6 months.
3 Infertility s.c or i.v 5 20 micrograms Injection Over one minute every 90 minutes for up to 6 months.

Ref :-  Book : Martindale    Page : 2280   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Diagnosis of hypothalamic-pituitary-gonadal dysfunction 1 Year 18 Year s.c or i.v 2.5 micrograms/kg Injection

Ref :- Book : Martindale    Page : 2281   Edition : 38  
►  Side Effect : Nausea, Abdominal pain, Abdominal discomfort, Hormonal milieu, mood changes, Nervousness, Palpitation, Acne, Dry skin, Changes in scalp and body hair, Alterations in liver function tests , Alterations in blood lipids, Decrease in glucose tolerance, Arthralgia, Paraesthesia, Thrombophlebitis, Swelling, pruritus, Hypersensitivity reactions, Bronchospasm, Anaphylaxis, Vaginal bleeding
Ref :-   Book : Martindale    Page : 2282   Edition : 38.  

►  Drug Interaction : Drug interaction of Gonadorelin is with , sex hormone ,  Spironolactone , Digoxin , Dopamine , Phenothiazine, Levodopa
Ref :-   Book : Martindale    Page : 2282   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Drugs affecting pituitary secretion of gonadotrophins may alter the response to gonadorelin or its analogues; other hormonal therapy and corticosteroids can affect the response. Spironolactone and levodopa can stimulate gonadotrophins while phenothiazines, dopamine antagonists, digoxin, and sex hormones can inhibit gonadotrophin secretion
Ref :-   Book : Martindale    Page : 2282   Edition : 38.  


►  Contraindication : In patients with pituitary adenoma as haemorrhagic infarction (pituitary apoplexy), Should be stopped if the patient becomes pregnant.
Ref :-   Book : Martindale    Page : 2282   Edition : 38.  
  ►  Mechanism of Action :   Continuous administration: inhibit LH and FSH release; pulsatile administration: stimulate LH and FSH release.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 479   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 2282   Edition : 38.  

►    Plasma Half-life :   Min value :-   10,    Max value :-   40 minutes.  
Ref :-   Book : Martindale    Page : 2282   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA