Griseofulvin is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 582   Edition : 38,

  ►   Brandname : Grisactin,Walavin,Grisol,Gris-PEG

  ►  Strength : Spray with   , Tablet with 125  mg, Tablet with 250  mg, Tablet with 125  mg, Tablet with 165  mg, Tablet with 250  mg, Tablet with 330  mg, Capsule with 250  mg, Oral Suspension with 125/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 582   Edition : 38, Basic & Clinical pharmacology    Page : 858   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Martindale    Page : 582   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Dermatophyte infections Oral 0.5 1 gm Daily in single or divided doses.
2 Tinea pedis Topical Spray 1 %.

Ref :-  Book : Martindale    Page : 582   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tinea capitis Oral 15 mg/kg 20 mg/kg
2 Dermatophyte infections 1 Month Oral 10 mg/kg 20 mg/kg

Ref :- Book : Martindale    Page : 582   Edition : 38,
►  Side Effect : headache, peripheral neuritis, lethargy, mental confusion, fatigue, syncope, vertigo, Blurred Vision, transient macular edema, augmentation of the effects of alcohol, nausea, vomiting, diarrhea, heartburn, Flatulence, dry mouth, angular stomatitis, hepatotoxicity, leucopenia, neutropenia, punctate basophilia, monocytosis, Common renal effects include Albuminuria and Cylindruria, cold and warm urticaria, photosensitivity, lichen planus, erythema, erythema multiforme, Rashes, serum-sickness-like syndrome, severe angioedema, Estrogen-like effects, fecal protoporphyrins,
Ref :-   Book : Goodman    Page : 1585,1586   Edition : 12, Goodman    Page : 1585   Edition : 12,

►  Drug Interaction : Drug interaction of Griseofulvin is with , Oral Contraceptive, Coumarin Anticoagulant, Alcohol,  Phenobarbital ,
Ref :-   Book : Martindale    Page : 583   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Phenobarbital has been reported to decrease the gastrointestinal absorption of griseofulvin. Plasma concentrations of griseofulvin have also been reported to be reduced by drugs that induce metabolising enzymes. Griseofulvin may increase the rate of metabolism and diminish the effects of some drugs such as coumarin anticoagulants and oral contraceptives. Griseofulvin may enhance the effects of alcohol. ,
Ref :-   Book : Martindale    Page : 582   Edition : 38,


►  Contraindication : severe liver disease, Systemic lupus erythematosus, contra-indicated in pregnancy and women should not become pregnant during, or within 1 month,
Ref :-   Book : Martindale    Page : 582   Edition : 37, Martindale    Page : 582   Edition : 38,
  ►  Mechanism of Action :   Griseofulvin inhibits microtubule function and thereby disrupts assembly of the mitotic spindle. Thus, a prominent morphological manifestation of the action of griseofulvin is the production of multinucleate cells as the drug inhibits fungal mitosis. griseofulvin's binding sites on the microtubular protein are distinct. In addition to its binding to tubulin, griseofulvin interacts with microtubule-associated protein. ,
Ref :-   Book : Goodman    Page : 1585   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tea tree oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • antifungal effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CHITOSAN with Alter the rate of absorption of water soluble drugs.,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Faecal, Renal, Sweat,
    Ref :-   Book : Martindale    Page : 583   Edition : 38,


    ►    Plasma Half-life :   Min value :-   9 ,    Max value :-   24 hours,
    Ref :-   Book : Martindale    Page : 583   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 583   Edition : 38,