Guanfacine is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1396   Edition : 38  

  ►   Brandname : Estulic, Intuniv, Tenex
  ►  Strength : Tablet with 1 mg mg.  Tablet with 2 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1396   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 1 mg Tablet daily increasing after 3 to 4 weeks to 2 mg daily if necessary.

Ref :-  Book : Martindale    Page : 1396   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hyperactivity disoder 6 Year and above Oral 1 mg Tablet o.d.

Ref :- Book : Martindale    Page : 1396   Edition : 38  
►  Side Effect : Dry mouth, Dizziness, Headache, Constipation, Depression, Anxiety, Fatigue, Nausea, Anorexia, Parotid pain, Sleep disturbances, Vivid dreams, impotence, Loss of libido, Urinary retention, Itching, Burning , Burning sensations in the eye, Fluid retention, Rashes, pruritus, Bradycardia, ECG disturbances, Heart failure, Cramps, Hallucinations, Raynaud’s syndrome, Gynaecomastia, Transient abnormalities in liver function tests, Increased blood pressure, Transient hypocalcaemia
Ref :-   Book : Martindale    Page : 1396,1341   Edition : 38.  

►  Drug Interaction : Drug interaction of Guanfacine is with Diuretics, Antihypertensive Agents , Beta Blockers , Isoenzyme Cytochrome P450, Tricyclic antidepressant , CNS depressant,  Betahistine, Isoflurane
Ref :-   Book : Martindale    Page : 1396,1341   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  The metabolism of guanfacine may altered bny strong inhibitors and inducers of the cytochrome p450 isoenzymes cyp3A4.The hypotensive effect of guanfacine may be enhanced by diuretics, other antihypertensives, and drugs that cause hypotension. However, beta blockers may exacerbate rebound hypertension following guanfacine withdrawal and tricyclic antidepressants may antagonise the hypotensive effect. The sedative effect of guanfacine may be enhanced by CNS depressants
Ref :-   Book : Martindale    Page : 1396,1341   Edition : 38.  


►  Contraindication : Caution in patients with cerebrovascular disease, ischaemic heart disease including myocardial infarction, renal impairment, occlusive peripheral vascular disorders such as Raynaud’s disease, or those with a history of depression., Drive or operate machinery where loss of attention could be dangerous
Ref :-   Book : Martindale    Page : 1396 ,1341   Edition : 38.   Nelson's textbook of Pediatrics    Page : 1396,1341   Edition : 38.  
  ►  Mechanism of Action :   Guanfacine is a centrally acting alpha2-adrenoceptor agonist with actions.
Ref :-   Book : Martindale    Page : 1396   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Useful in the treatment of Anxiety . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1396   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   30 hours.  
    Ref :-   Book : Martindale    Page : 1396   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 1396   Edition : 38.