Haloperidol is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1106   Edition : 37  

  ►   Brandname : Cizoren, Serenace, Haldol, Dozic
  ►  Strength : Tablet with 0.5 mg.  Tablet with 1 mg.  Tablet with 2 mg.  Tablet with 5 mg.  Tablet with 10 mg.  Tablet with 20 mg.  Injection with 5 mg/ml.  Capsule with .  Oral solution with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12   Martindale    Page : 1106   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, SC
Reference :-   Book : Martindale    Page : 1105   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Psychoses and associated behavioural disorders Oral 0.5 5 mg b.d/t.i.d
2 Acute psychotic conditions IM 2 10 mg Injection Dose: Given subsequent doses may be given hourly, until symptoms are controlled, although dosage intervals of 4 to 8 hours may be adequate, up to a maximum of 18 mg daily.
3 Tourette’s syndrome Oral 0.5 1.5 mg t.i.d.
4 Severe tics Oral 0.5 1.5 mg t.i.d.
5 Hiccups Oral 1.5 mg t.i.d. Dose: Adjusted according to response
6 Anxiety disorders Oral 500 micrograms b.d. Dose: used as adjunctive treatment
7 Restlessness and confusion Oral 1 3 mg Dose: In palliative care: Given every 8 hours.
8 Restlessness and confusion SC infusion 5 15 mg Injection Dose: In palliative care: Given over 24 hours

Ref :-  Book : Martindale    Page : 1105   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia and behavioural disorders Oral 25 50 micrograms/kg
2 Tourette’s syndrome Oral up to 10 mg
3 Severe tics Oral up to 10 mg
4 Restlessness and confusion Oral 10 20 micrograms/kg

Ref :- Book : Martindale    Page : 1105   Edition : 37  
Precaution :- If a Patient is using 'Haloperidol' drug in  Gynecomastia  disease, then Please contraindicated .

►  Side Effect : Dry mouth, Constipation, Difficulty in micturition, Blurred Vision, Mydriasis, Tachycardia, ECG changes, Hypotension, Delirium, Agitation, Hypersensitivity reactions, Urticaria, Exfoliative dermatitis, Erythema multiforme, Contact sensitivity, Photosensitivity reactions, Haemolytic anaemia, Aplastic anaemia, Thrombocytopenic purpura, Eosinophilia, Fatal agranulocytosis
Ref :-   Book : Martindale    Page : 1072,1104   Edition : 37.  

►  Drug Interaction : Drug interaction of Haloperidol is with Tricyclic antidepressants, Alcohol, General anaesthetics , Hypnotics, Anxiolytics, Opoids, , , , Antimalarials, Diuretics,  Lacosamide , Cisapride
Ref :-   Book : Martindale    Page : 1076,1105   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  The metabolism of haloperidol is mediated by several routes including the cytochrome P450 system, particularly the isoenzymes CYP3A4 and CYP2D6. Therefore, there is a potential for interactions between haloperidol and other drugs that induce, inhibit, or act as a substrate for these isoenzymes, resulting in altered haloperidol concentrations; it may be necessary to amend the dosage of haloperidol when given such drugs. Haloperidol itself is also an inhibitor of CYP2D6 and may increase the plasma concentrations of tricyclic antidepressants by inhibiting their metabolism. Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. When given with other drugs that produce orthostatic hypotension, dosage adjustments may be necessary. There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval.
Ref :-   Book : Martindale    Page : 1076,1105   Edition : 37.  

►  Contraindication : Phaeochromocytoma, Bone marrow suppression, Pre-existing CNS depression or coma, Prolactin-dependent tumours, Hepatic impairment, Renal impairment, Cardiovascular impairment, Cerebrovascular impairment, Respiratory function impairment, Angle-closure glaucoma, History of jaundice, Parkinsonism, Diabetes mellitus, Hypothyroidism, Myasthenia gravis, Paralytic ileus, prostatic hyperplasia, Urinary retention, Haloperidol should be used with great care in children and adolescents as they may be at increased risk of severe dystonic reactions; patients with hyperthyroidism may also be at increased risk, The risk of QT prolongation and/or ventricular arrhythmias may be increased with high doses or with parenteral use of haloperidol, particularly intravenous administration
Ref :-   Book : Martindale    Page : 1075,1104   Edition : 37.  
  ►  Mechanism of Action :   Antagonize mesolimbic, and possibly mesocortical, D2 receptors.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 204   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine antagosit drug.   EVENING PRIMROSE OIL with Potential risk of seizures.   KAVA with Cause excessive drawsiness.  

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 1105   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   12 hours,    Max value :-   38 hours.  
    Ref :-   Book : Martindale    Page : 1105   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : .