Halothane is a Medicine belongs to General anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1941   Edition : 37,

  ►   Brandname : Fluothane

  ►  Strength : Liquid with 125  mL, Liquid with 250  mL,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation,
Reference :-   Book : Martindale    Page : 1941   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Induction of anaesthesia inhalation 0.5% v/v Liquid Dose: Halothane in oxygen or mixture of nitrous oxide and oxygen, and increased gradually, according to response, to a concentration 2 to 4% v/v. It takes up to about 5 minutes to attain surgical anaesthesia and halothane produces little or no excitement in the induction period. The more usual practice is to induce anaesthesia with an intravenous agent. Anaesthesia is maintained with concentrations of 0.5 to 2% v/v depending on the flow rate used; the lower concentration is usually suitable for the elderly.

Ref :-  Book : Martindale    Page : 1941   Edition : 37,

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Induction of anaesthesia

Ref :- Book : Martindale    Page : 1941   Edition : 37,
►  Side Effect : nausea, vomiting, shivering, Malignant hyperthermia, involuntary muscle movements, hiccup, coughing, bronchospasm, laryngospasm, respiratory depression, hypotension, Cardiac arrhythmias, mild hypothermia, anorexia, malaise, fatigue, Dizziness, headache, dry mouth, Jaw pain,
Ref :-   Book : Martindale    Page : 1935,1940   Edition : 37,

►  Drug Interaction : Drug interaction of Halothane is with Epinephrine (adrenaline) , Theophylline , Atracurium , trimethaphan, morphine, Chlorpromazine , Ergometrine , Oxytocin ,
Ref :-   Book : Martindale    Page : 1941   Edition : 37,

  ►    Mechanism of Drug Drug Interaction :  Adrenaline and most other sympathomimetics, and theophylline should be avoided during halothane anaesthesia since they can produce cardiac arrhythmias; the risk of arrhythmias is also increased if halothane is used in patients receiving dopaminergics. The effects of competitive neuromuscular blockers such as atracurium, and of ganglion blockers such as trimetaphan are enhanced by halothane and if required they should be given in reduced dosage. Morphine increases the depressant effects of halothane on respiration. Chlorpromazine also enhances the respiratory depressant effect of halothane. The effects of both ergometrine and oxytocin on the parturient uterus are diminished by halothane.,
Ref :-   Book : Martindale    Page : 1941   Edition : 37,

►  Contraindication : Obstetrical anaesthesia, Susceptibility to malignant hyperthermia, History of hepatic change from previous halothane exposure,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 260   Edition : 3,
  ►  Mechanism of Action :   General anesthetics, mechanism of action remains unknown. In recent years this “unitary theory” of anesthetic action has been supplanted by a more complex picture of molecular targets located at multiple levels of the central nervous system (CNS). Anesthetics affect neurons at various cellular locations, but the primary focus has been on the synapse. A presynaptic action may alter the release of neurotransmitters, whereas a postsynaptic effect may change the frequency or amplitude of impulses exiting the synapse. At the organ level, the effect of anesthetics may result from strengthening inhibition or from diminishing excitation within the CNS. Studies on isolated spinal cord tissue have demonstrated that excitatory transmission is impaired more strongly by anesthetics than inhibitory effects are potentiated. Chloride channels (γ-aminobutyric acid-A [GABA A ] and glycine receptors) and potassium channels (K 2P , possibly K v , and K ATP channels) remain the primary inhibitory ion channels considered legitimate candidates of anesthetic action. Excitatory ion channel targets include those activated by acetylcholine (nicotinic and muscarinic receptors), by excitatory amino acids (amino-3-hydroxy-5-methyl- 4-isoxazol-propionic acid [AMPA], kainate, and N -methyl- D - aspartate [NMDA] receptors), or by serotonin (5-HT 2 and 5-HT 3 receptors).,
Ref :-   Book : Basic & Clinical pharmacology    Page : 429,430   Edition : 12,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

Dietry Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication Dietry Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   lungs, Renal,
Ref :-   Book : Martindale    Page : 1941   Edition : 37,

►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA