Homatropine is a Medicine belongs to anticholinergic group whose information about Brand can be referenced from   Book : Martindale    Page : 2008   Edition : 38,

  ►   Brandname : Homide,Homarin

  ►  Strength : Ophthalmic Solution with 1  %, Ophthalmic Solution with 2  %, Ophthalmic Solution with 5  %,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2008   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, ophthalmic,
Reference :-   Book : Martindale    Page : 2008   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 To produce mydriasis ophthalmic 1 % Ophthalmic Solution
2 To produce mydriasis ophthalmic 2 % Ophthalmic Solution
3 To produce mydriasis ophthalmic 5 % Ophthalmic Solution
4 To produce cycloplegia ophthalmic 1 % Ophthalmic Solution
5 To produce cycloplegia ophthalmic 2 % Ophthalmic Solution
6 To produce cycloplegia ophthalmic 5 % Ophthalmic Solution
7 Uveitis ophthalmic 1 % Eye Drop b.d. Dose: Given or up to every 3 to 4 hours if required.
8 Uveitis ophthalmic 2 % Eye Drop b.d. Dose: Given or up to every 3 to 4 hours if required.
9 Uveitis ophthalmic 5 % Eye Drop b.d. Dose: Given or up to every 3 to 4 hours if required.
10 Uveitis ophthalmic 5 % Eye Drop t.i.d. Dose: Given or up to every 3 to 4 hours if required.
11 Uveitis ophthalmic 2 % Eye Drop t.i.d. Dose: Given or up to every 3 to 4 hours if required.
12 Uveitis ophthalmic 1 % Eye Drop t.i.d. Dose: Given or up to every 3 to 4 hours if required.

Ref :-  Book : Martindale    Page : 2008   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 ophthalmic 0.5 % Eye Drop o.d.
2 Uveitis 3 Month 2 Year ophthalmic 0.5 1 % Eye Drop b.d.

Ref :- Book : Martindale    Page : 2008   Edition : 38,
►  Side Effect : Dryness of the mouth, Difficulty in swallowing and talking, thirst, reduced bronchial secretions, mydriasis, cycloplegia, photophobia, flushing, dryness of the skin, transient bradycardia, tachycardia, palpitations, arrhythmia, difficulty in micturition, constipation, constipation,
Ref :-   Book : Martindale    Page : 1312,2008   Edition : 38,

►  Drug Interaction : Drug interaction of Homatropine is with , Phenothiazine antipsychotics, Monoamine Oxidase Inhibitor, Parasympathomimetics,  Amantadine , Cisapride , Domperidone , Metoclopramide ,
Ref :-   Book : Martindale    Page : 1312,2008   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The effects of atropine and other antimuscarinics may be enhanced by use with other drugs having antimuscarinic properties, such as amantadine, some antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. The reduction in gastric motility caused by antimuscarinics may affect the absorption of other drugs. Antimuscarinics may also antagonise the gastrointestinal effects of cisapride, domperidone, and metoclopramide. Antimuscarinics and parasympathomimetics may counteract each others effects,
Ref :-   Book : Martindale    Page : 1312,2008   Edition : 38,


►  Contraindication : prostatic enlargement, paralytic ileus, diarrhoea, angle -closure glucoma, infants aged less than 3 months,
Ref :-   Book : Martindale    Page : 1312,2008   Edition : 38,
  ►  Mechanism of Action :   It is a tertiary amine antimuscarinic alkaloid with both central and peripheral actions. It is usually given as the sulfate. It first stimulates and then depresses the CNS and has antispasmodic actions on smooth muscle and reduces secretions, especially salivary and bronchial secretions; it also reduces perspiration, but has little effect on biliary or pancreatic secretion. It depresses the vagus and thereby increases the heart rate.,
Ref :-   Book : Martindale    Page : 1310,2008   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA