Human normal immunoglobulin is a Medicine belongs to Immunoglobulin group whose information about Brand can be referenced from   Book : Martindale    Page : 2437   Edition : 37,

  ►   Brandname : Intragam, Octagam, Sandoglobulin, Beriglobin, Endobulin, Flebogamma, Gamafine, Flebogamma, Gammabulin, Carimune, Flebogamma

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2434   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV, SC,
Reference :-   Book : Martindale    Page : 2433   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hepatitis A IM 500 mg Injection
2 Measles IM 750 mg Injection
3 Rubella infection IM 750 mg Injection Normal immunoglobulin does not prevent rubella infection and is not recommended for the protection of pregnant women exposed to rubella; it should only be considered where termination of pregnancy is unacceptable.
4 Primary antibody deficiency IV infusion 400 800 mg/kg Injection Dose: then 200 mg/kg every 3 weeks adjusted as necessary according to trough-immunoglobulin concentrations; the maintenance dose is usually 200 to 800 mg/kg per month.
5 Bone marrow transplantation IV 500 mg/kg Injection Dose: Given weekly, adjusted according to response.
6 Idiopathic thrombocytopenic purpura IV infusion 400 mg/kg Injection Dose: Given daily, for 2 to 5 consecutive days. Alternatively, a dose of 800 to 1000 mg/kg may be given on day 1 and repeated on day 3 if necessary. Further doses may be given as necessary.
7 Kawasaki disease IV 1.6 2 gm/kg Injection Dose: Given in divided doses over 2 to 5 days, or 2 g/kg given as a single dose.
8 Guillain- Barre syndrome IV 400 mg/kg Injection Dose: Given for 5 consecutive days, repeated every 4 weeks if required
9 Secondary immunodeficiency syndromes IV infusion 200 400 mg/kg Injection Dose: Given every 3 to 4 weeks.

Ref :-  Book : Martindale    Page : 2434   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hepatitis A 10Year IM 250 mg Injection
2 Measles 1Year IM 250 mg Injection
3 Measles 1 Year 3 Year IM 500 mg Injection

Ref :- Book : Martindale    Page : 2434   Edition : 37,
►  Side Effect : Local reactions with pain and tenderness, hypersensitivity reactions, fever, chills, facial flushing, headache, nausea, ,
Ref :-   Book : Martindale    Page : 2406,2433   Edition : 37,

►  Drug Interaction : Drug interaction of Human normal immunoglobulin is with NA

  ►    Mechanism of Drug Drug Interaction :  Normal immunoglobulin may interfere with the immune response to live viral vaccines. Such vaccines should therefore be given at least 3 weeks before, or 3 months after, normal immunoglobulin,
Ref :-   Book : Martindale    Page : 2434   Edition : 37,


►  Contraindication : renal impairment, renal failure, Pre-existing risk factors for thrombotic events,
Ref :-   Book : Martindale    Page : 2433   Edition : 37,
  ►  Mechanism of Action :   An intramuscular injection used for passive immunisation and some time also for primary antibody deficiencies,
Ref :-   Book : Martindale    Page : 2434   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA