Hydralazine is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1438   Edition : 37,

  ►   Brandname : Alphapress, Apresoline

  ►  Strength : Tablet with 10  mg, Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg, Injection with 20  mg/ml, Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12, Martindale    Page : 1438   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 1437   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypertensive crises Slow IV 5 10 mg Injection Dose: Repeated if necessary after 20 to 30 minutes.
2 hypertension Oral 40 50 mg Dose:Given daily in divided doses, increased according to response.
3 Heart failure Oral 37.5 mg t.i.d. Dose: In self-identified black patients, given with 20 mg of isosorbide dinitrate, and may be doubled if necessary.
4 Hypertension crises continuous i.v infusion 200 300 micrograms/minute Injection Dose: The usual maintenance dose range is 50 to 150 micrograms/minute.

Ref :-  Book : Martindale    Page : 1437-1438   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension Oral 250 500 micrograms/kg
2 hypertension 1Month Oral 7.5 mg/kg
3 hypertension slow i.v 100 500 micrograms/kg Injection
4 hypertension 12Year Slow IV 5 10 mg Injection
5 hypertension continuous i.v infusion 12.5 50 microgram/kg/hour Injection
6 hypertension 12Year continuous i.v infusion 3 9 mg/hour Injection
7 hypertension 12 Year

Ref :- Book : Martindale    Page : 1438   Edition : 37,
Precaution :- If a Patient is using 'Hydralazine' drug in heart failure disease, then Please should be used instead of ace inhibitors   if he ever suffered from acute kidney injury disease.
►  Side Effect : tachycardia, palpitations, angina pectoris, severe headache, gastrointestinal disturbance, anorexia, nausea, vomiting, diarrhoea, flushing, Dizziness, nasal congestion, Orthostatic hypotension, oedema, weight gain, conjunctivitis, Lacrimation, tremor, muscle cramp, peripheral neuropathy, Numbness, tingling of the extremities, hepatotoxicity, blood dyscrasias, haemolytic anaemia, difficulty urinating, glomerulonephritis, constipation, paralytic ileus, Depression, anxiety, fever, chills, pruritus, Rashes, eosinophilia,
Ref :-   Book : Martindale    Page : 1436   Edition : 37,

►  Drug Interaction : Drug interaction of Hydralazine is with Thiazide Diuretics , Beta Blockers ,  Diazoxide ,
Ref :-   Book : Martindale    Page : 1437   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The hypotensive effect of hydralazine may be enhanced by other drugs with a hypotensive action. Severe hypotension may occur if hydralazine and diazoxide are given together. However, some interactions with antihypertensives may be beneficial: thiazide diuretics also counteract the fluid retention caused by hydralazine, and beta blockers diminish the cardiac-accelerating effects. ,
Ref :-   Book : Martindale    Page : 1437   Edition : 37,


►  Contraindication : Severe tachycardia, dissecting aortic aneurysm, Heart failure with high cardiac output, cor pulmonale, Myocardial insufficiency due to mechanical obstruction, aortic or mitral stenosis , constrictive pericarditis, Idiopathic SLE and related disorders, hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 1437   Edition : 37,
  ►  Mechanism of Action :   Arteriolar vasodilator. mechanism of action is unclear; proposed mechanism include membrane hyperpolarization, potassium channel activation, and inhibition of IP3-induced ca release from sarcoplasmic reticulum in vascular smooth muscle.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 371   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Celery with Another pathway,

  ►  Pathway with its reference as follows :-
  • Diuretic properties --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FOLATE with Impairs folate metabolism , VITAMIN B6 with Increases urinary vit B6 excretion.,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1437   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1437   Edition : 37,