Hydrocortisone is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 1676   Edition : 37,

  ►   Brandname : Cipcorlin,Cutisoft,Entofoam,Acticort,Ala-cort,Colifoam,Cortopin,Colifoam, Cortaid, Cortef, Alfason, Dermallerg

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg, Tablet with 20  mg, Injection with 20, 50  mg/ml, Suspension with 10  mg/5mL, Injection with 50  mg/ml, Injection with 100,250,500,1000  mg/vial, Enema with 100  mg/60mL, Intrarectal foam with 90  mg, Cream with 0.5  %, Cream with 1  %, Ointment with 0.5  %, Ointment with 1  %, Lotion with 0.5  %, Lotion with 1  %, Gel with 1  %, Spray with 1  %, Aerosol with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 712,1112,1120   Edition : 12, Basic & Clinical pharmacology    Page : 712,1112,1120   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : rectal, Topical, IV, IM, Oral,
Reference :-   Book : Martindale    Page : 1675   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Replacement therapy in acute or chronic adrenocortical insufficiency Oral 20 30 mg Dose: Given daily, (usually taken in 2 doses, the larger in the morning and the smaller in the early evening, to mimic the circadian rhythm of the body).
2 Acute adrenocortical insufficiency IV infusion 100 500 mg Injection Dose: repeated 3 or 4 times in 24 hours, according to the severity of the condition and the patient’s response.
3 Skin disorders Topical 0.1 2.5 % Cream
4 Skin disorders Topical 0.1 2.5 % Ointment
5 Skin disorders Topical 0.1 2.5 % Lotion

Ref :-  Book : Martindale    Page : 1675   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Replacement therapy in adrenocortical insufficiency Oral 4 5 mg/m2
2 Replacement therapy in adrenocortical insufficiency 1 Month 18 Year Oral 4 5 mg/m2
3 Congenital Adrenal Hyperplasia Oral 6 7 mg/m2
4 Congenital Adrenal Hyperplasia 1 Month 18 Year Oral 5 6.5 mg/m2
5 Acute adrenocortical insufficiency Slow IV 10 mg Injection
6 Acute adrenocortical insufficiency 1 Month 12 Year slow IV injection/infusion 2 4 mg/kg Injection
7 Acute adrenocortical insufficiency 12 Year 18 Year slow IV injection/infusion 100 mg Injection

Ref :- Book : Martindale    Page : 1675   Edition : 37,
►  Side Effect : Mobilisation of calcium and phosphorus, osteoporosis, spontaneous fractures, muscle wasting, nitrogen depletion, Hyperglycaemia with accentuation or precipitation of the diabetic state, insulin requirements of diabetic patients are increased, Increased appetite, delayed wound healing, Increased susceptibility to all kinds of infection, including septicaemia, tuberculosis, fungal infections, and viral infections, Increased susceptibility to all kinds of infection, including septicaemia, tuberculosis, fungal infections, and viral infections, Infections may also be masked by the anti-inflammatory, analgesic, and antipyretic effects of glucocorticoids, Increased severity of varicella and measles may lead to a fatal outcome in non-immune patients receiving systemic corticosteroid therapy, menstrual irregularities, amenorrhoea, Hyperhidrosis, skin thinning, ocular changes, glaucoma, cataract, mental disturbances, neurological disturbances, benign intracranial hypertension, acute pancreatitis, avascular necrosis of bone, adrenal atrophy, Secondary adrenocortical insufficiency, High doses of corticosteroids given during pregnancy may cause fetal or neonatal adrenal suppression, Large doses of corticosteroids, or of corticotropin, may produce Cushingoid symptoms typical of hyperactivity of the adrenal cortex, with moon-face, sometimes with hirsutism, buffalo hump, flushing, increased bruising, ecchymoses, striae, and acne, Giving large intravenous doses of corticosteroids too rapidly may cause cardiovascular collapse, corneal ulcers, raised intra-ocular pressure, reduced visual function, Dryness, Irritation, epistaxis, Adverse effects should be treated symptomatically, with the corticosteroid dosage reduced or slowly withdrawn where possible, Retention of sodium and water, with oedema and hypertension, and in the increased excretion of potassium with the possibility of hypokalaemic alkalosis, Disturbances of electrolyte balance,
Ref :-   Book : Martindale    Page : 1628-1629,1675   Edition : 37,

►  Drug Interaction : Drug interaction of Hydrocortisone is with Salicylates, NSAIDS, Beta 2 Agonist, , Thiazide Diuretics , Potassium-depleting diuretics, Oral Contraceptive, Barbiturates ,  Amphotericin B , Furosemide , Ritonavir, Rifampicin , Primidone , Phenytoin , Carbamazapine ,
Ref :-   Book : Martindale    Page : 1632,1675   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Concurrent use of barbiturates, carbamazepine, phenytoin, primidone, or rifampicin may enhance the metabolism and reduce the effects of systemic corticosteroids. Conversely oral contraceptives or ritonavir may increase plasma concentrations of corticosteroids. Use of corticosteroids with potassium-depleting diuretics, such as thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalaemia with concurrent amphotericin B or bronchodilator therapy with xanthines or beta2 agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when corticosteroids are given with NSAIDs. Response to anticoagulants may be altered by corticosteroids and requirements of antidiabetic drugs and antihypertensives may be increased. Corticosteroids may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravi.,
Ref :-   Book : Martindale    Page : 1632,1675   Edition : 37,


►  Contraindication : heart failure, recent myocardial infarction, hypertension, Diabetes mellitus, Epilepsy, Glaucoma, Hypothyroidism, Hepatic failure, osteoporosis, Peptic ulceration, Psychoses, Severe affective disorders, renal impairment, acute infections uncontrolled by appropriate antimicrobial therapy, Patients with active or doubtfully quiescent tuberculosis, Sodium intake may need to be reduced and calcium and potassium supplements may be necessary, Children are at special risk from raised intracranial pressure, They should not be applied with an occlusive dressing to large areas of the body,
Ref :-   Book : Martindale    Page : 1631,1675   Edition : 37,
  ►  Mechanism of Action :   Hydrocortisone bind to specific receptor proteins in target tissues to regulate the expression of corticosteroid-responsive genes, thereby changing the levels and array of proteins synthesized by the various target tissues. As a consequence of the time required to modulate gene expression and protein synthesis, most effects of corticosteroids are not immediate but become apparent after several hours. This fact is of clinical significance because a delay generally is seen before beneficial effects of corticosteroid therapy become manifest.,
Ref :-   Book : Goodman    Page : 1216-1217   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway, Ashwagandha with Another pathway, Evening primrose oil with Another pathway, Zinc with Another pathway, Vitamin A with Another pathway, Broccoli with Another pathway, Quercetin with Another pathway, Parsley with Another pathway, Rosemary with Another pathway, Oregano with Another pathway, Thyme with Another pathway, Chammomila with Another pathway, Tulsi with Another pathway,

  ►  Pathway with its reference as follows :-
  • withanine have antiinflammatory effect --- (kokate, C. (2013). Pharmacognosy (4th ed.). Mumbai: Nirali Prakashan. )
  • Withanine have Anti-inflammatory --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • withanine have antiinflammatory effect --- (kokate, C. (2013). Pharmacognosy (4th ed.). Mumbai: Nirali Prakashan. )
  • Withanine have Anti-inflammatory --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Act as nerve stimulant . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Zinc help in destroying viral infection. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Vit A has strong antiviral activity. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Broccoli rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Quercetin enhance the antiviral activity of aciclovir --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Parsley rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Rosemary rich in apigenin enhance the antiviral activity of aciclovir . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Oregano rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Thyme rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Chammomila rich in apigenin enhance the antiviral activity of aciclovir --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Tulsi rich in epigenin enhane the antiviral activity of aciclovir . --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FRANGULA I.E. RHAMNUS FRANGULA with frangula interact with carticosteroid .,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1675   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA