Hydroflumethiazide is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 1442   Edition : 37  

  ►   Brandname : Saluron, Aldactide, Salutensin
  ►  Strength : Tablet with 50 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1442   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 50 200 mg Tablet Dose: (usual initial dose) Given daily, in one or two divided doses, in one or two divided doses, reduced to a dose of 25 to 50 mg on alternate days or intermittently
2 hypertension Oral 25 50 mg Tablet Dose: (usual dose) Given daily either alone, or with other antihypertensives. An initial dose of 12.5 mg has been used.

Ref :-  Book : Martindale    Page : 1442   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension Oral 1 mg/kg Tablet
2 Oedema Oral 1 mg/kg Tablet

Ref :- Book : Martindale    Page : 1442   Edition : 37  
►  Side Effect : Dry mouth, Thirst, Weakness, Lethargy, Drowsiness, Restlessness, Restlessness, Muscle pain, Cramps, Seizure, Oliguria, Hypotension, Gastrointestinal disturbance, Anorexia, Gastric irritation, Nausea, Vomiting, Vomiting, Constipation, Diarrhoea, Sialadenitis, Headache, Dizziness, Dizziness, Photosensitivity reactions, Paraesthesia, impotence, Yellow vision, Hypersenstivity, Skin rashes, Fever, Pulmonary oedema, Pneumonitis, Toxic epidermal necrolysis, Anaphylaxis, Cholestatic jaundice, Cholestasis, Blood dyscrasias, Thrombocytopenia
Ref :-   Book : Martindale    Page : 1438,1442   Edition : 37.  

►  Drug Interaction : Drug interaction of Hydroflumethiazide is with , , Beta 2 Agonist, Alpha blocker, Angiotensin converting enzyme inhibitor, Alcohol, Barbiturates , Opoids, Non Sterodial Anti- Inflammatory Drugs , , TETRACYCLINES ,  Astemizole, Terfenadine, Halofantrine, Pimozide , Sotalol , Atracurium , Corticotropin , Salbutamol , Carbenoxolone, Amphotericin B , Reboxetine, Carbenoxolone, Noradrenaline/Norepinephrine
Ref :-   Book : Martindale    Page : 1440,1442   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Many of the interactions of hydrochlorothiazide and other thiazides are due to their effects on fluid and electrolyte balance. Diuretic-induced hypokalaemia may enhance the toxicity of digitalis glycosides and may also increase the risk of arrhythmias with drugs that prolong the QT interval, such as astemizole, terfenadine, halofantrine, pimozide, and sotalol. Thiazides may enhance the neuromuscular blocking action of competitive neuromuscular blockers, such as atracurium, probably by their hypokalaemic effect. The potassium- depleting effect of diuretics may be enhanced by corticosteroids, corticotropin, beta2 agonists such as salbutamol, carbenoxolone, amphotericin B, or reboxetine. Diuretics may enhance the effect of other antihypertensives, particularly the first-dose hypotension that occurs with alpha blockers or ACE inhibitors. Orthostatic hypotension associated with diuretics may be enhanced by alcohol, barbiturates, or opioids. The antihypertensive effects of diuretics may be antagonised by drugs that cause fluid retention, such as corticosteroids, NSAIDs, or carbenoxolone; diuretics may enhance the nephrotoxicity of NSAIDs. Thiazides have been reported to diminish the response to pressor amines, such as noradrenaline, but the clinical significance of this effect is uncertain. Thiazides should not usually be used with lithium since the association may lead to toxic blood concentrations of lithium. Other drugs for which increased toxicity has been reported when given with thiazides include allopurinol and tetracyclines. Thiazides may alter the requirements for hypoglycaemics in diabetic patients.
Ref :-   Book : Martindale    Page : 1440,1442   Edition : 37.  

►  Contraindication : Preexisting hypercalcaemia, Anuria, Severe renal impairment, Addison’s disease , Severe hepatic impairment
Ref :-   Book : Martindale    Page : 1440,1442   Edition : 37.  
  ►  Mechanism of Action :   Inhibit sodium chloride reabsorption by acting competitive antagonists at NCC sodium chloride co- transporter in apical (luminal) membrane of distal convoluted tubule cells; promote increased transcellular calcium reabsorption in distal convoluted tubule.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 352   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- IRON with Decrease in Nutrient Level.  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Goodman    Page : 688   Edition : 12.  

    ►    Plasma Half-life :   Min value :-   ~17 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 688   Edition : 12.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA