Hydroxycarbamide (Hydroxyurea) is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 801   Edition : 37,

  ►   Brandname : Droxia,Hydrea,Cytodrox,Litalir, Syrea

  ►  Strength : Capsule with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 801   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 800   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic myeloid leukemia Oral 20 30 mg/kg Capsule Dose: Given daily, or in a single dose of 80 mg/kg every third day.
2 Solid tumours Oral 20 30 mg/kg Capsule Dose: Given daily, or in a single dose of 80 mg/kg every third day.
3 Polycythaemia vera Oral 15 20 mg/kg Capsule Dose: Given daily, Doses are subsequently adjusted according to platelet counts.
4 Sickle-cell disease Oral 15 mg/kg Capsule Dose: given daily, increased if necessary by 5 mg/kg daily every 12 weeks according to response and blood counts, up to a maximum of 35 mg/kg daily.
5 Essential thrombocythaemia Oral 15 mg/kg Capsule Dose: (initial dose) Given daily, Doses are subsequently adjusted according to platelet counts.

Ref :-  Book : Martindale    Page : 800   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Sickle-cell disease 2 Year 18 Year Oral 10 15 mg/kg Capsule o.d.

Ref :- Book : Martindale    Page : 800   Edition : 37,
►  Side Effect : Bone marrow suppression, megaloblastic changes, irradiation, gastrointestinal disturbance, impairment of renal function, pulmonary edema, dermatological reactions, headache, Dizziness, drowsiness, disorientation, hallucinations, convulsion, cutaneous vasculitis, vasculitic ulcerations, gangrene, hepatotoxicity, Pancreatitis, alopecia, , ,
Ref :-   Book : Martindale    Page : 799   Edition : 37,

►  Drug Interaction : Drug interaction of Hydroxycarbamide (Hydroxyurea) is with NA

  ►    Mechanism of Drug Drug Interaction :  Because of their effects on the gastrointestinal mucosa antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalised infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted.,
Ref :-   Book : Martindale    Page : 698,800   Edition : 37,


►  Contraindication : Severe bone marrow depression,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 695   Edition : 3,
  ►  Mechanism of Action :   Hydroxycarbamide is an antineoplastic that may cause inhibition of DNA synthesis by acting as a ribonucleotide reductase inhibitor. It is S-phase specific.,
Ref :-   Book : Martindale    Page : 800   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cancer tree with Another pathway,

  ►  Pathway with its reference as follows :-
  • anticancer effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 800   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 800   Edition : 37,