Hydroxychloroquine is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Martindale    Page : 658   Edition : 37,

  ►   Brandname : HCQS,Plaquenil

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 658   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 658   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Lupus erythematosus Oral 400 mg Tablet o.d/b.d Doses are reduced to the minimum effective dose for maintenance; this is usually 200 to 400 mg daily but should not exceed 6.5 mg/kg daily (or 400 mg daily whichever is the smaller).
2 Rheumatoid arthiritis Oral 400 600 mg Tablet Doses are reduced to the minimum effective dose for maintenance; this is usually 200 to 400 mg daily but should not exceed 6.5 mg/kg daily (or 400 mg daily whichever is the smaller).
3 Prophylaxis of malaria Oral 400 mg Tablet Dose: Given every 7 days.
4 Acute malarial attack Oral 800 mg Tablet Dose: followed after 6 to 8 hours by 400 mg and a further 400 mg on each of the 2 following days; alternatively, a single dose of 800 mg has been given

Ref :-  Book : Martindale    Page : 657-658   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Rheumatoid arthiritis Oral 6.5 mg/kg Tablet
2 Light sensitive skin eruption Oral 6.5 mg/kg
3 Light sensitive skin eruption Oral 6.5 mg/kg Tablet
4 Treatment of malaria Oral 13 mg/kg Tablet
5 Prophylaxis of malaria Oral 6.5 mg/kg Tablet QWK
6 Lupus erythematosus Oral 6.5 mg/kg Tablet

Ref :- Book : Martindale    Page : 658   Edition : 37,
Precaution :- If a Patient is using 'Hydroxychloroquine' drug in  Malaria  disease, then Please be avoided in patients of Psoriasis .

►  Side Effect : headache, skin eruptions, pruritus, Gastrointestinal disturbances, nausea, vomiting, diarrhoea, Polyneuritis, convulsion, keratopathy, Loss of hair, Bleaching of hair pigment, Bluishblack pigmentation of the mucous membranes and skin, photosensitivity, tinnitus, Reduced hearing, Nerve deafness, neuropathy, myopathy, cardiomyopathy, drowsiness, Dizziness, hypokalaemia, ,
Ref :-   Book : Martindale    Page : 652,657   Edition : 37, Martindale    Page : 652,657   Edition : 652,

►  Drug Interaction : Drug interaction of Hydroxychloroquine is with , Antacid ,  Carbamazapine , Valproic acid(sodium valproate), Cimetidine , kaolin, Mefloquine , Moxifloxacin , Amiodarone , Halofantrine,
Ref :-   Book : Martindale    Page : 654,657,2463   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of inducing ventricular arrhythmias if it is used with halofantrine or other arrhythmogenic drugs such as amiodarone and moxifloxacin. There is an increased risk of convulsions when it is given with mefloquine. The absorption of chloroquine can be reduced by antacids or kaolin and its metabolism may be inhibited by cimetidine. Agalsidase alfa or beta should not be used with amiodarone, chloroquine, monobenzone, or gentamicin, which all have the potential to inhibit intracellular α-galactosidase activity. It may antagonise the antiepileptic activity of carbamazepine and valproate by lowering the convulsive threshold.,
Ref :-   Book : Martindale    Page : 654,657,2463   Edition : 37,


►  Contraindication : hepatic impairment, myasthenia gravis, renal impairment, severe gastrointestinal disorders, history of psoriasis, history of epilepsy, Patients with G6PD deficiency should be observed for haemolytic anaemia during chloroquine treatment,
Ref :-   Book : Martindale    Page : 654,657   Edition : 37,
  ►  Mechanism of Action :   The mechanism of the anti-inflammatory action of this drug in rheumatic diseases is unclear. The following mechanisms have been proposed: suppression of T-lymphocyte responses to mitogens, decreased leukocyte chemotaxis, stabilization of lysosomal enzymes, inhibition of DNA and RNA synthesis, and the trapping of free radicals.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 644   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Gun resin i.e. Boswellia serrata with Another pathway,

  ►  Pathway with its reference as follows :-
  • Resin acid have antimalerial property --- (Duke, J. & Duke, J. (2002). Handbook of medicinal herbs. Boca Raton, FL: CRC Press. )

  •   ►  URL -- https://books.google.co.in/books?id=vPTLBQAAQBAJ&printsec=frontcover&dq=Duke, +J.+%26+Duke, +J.+(2002).+Handbook+of+medicinal+herbs.+Boca+Raton, +FL:+CRC+Press.&hl=en&sa=X&redir_esc=y#v=onepage&q=Duke%2C%20J.%20%26,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 654   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA