Hydroxycobalamin is a Medicine belongs to Nutritional agent and vitamin group whose information about Brand can be referenced from   Book : Martindale    Page : 2145   Edition : 37,

  ►   Brandname : Calomist,Cytamen,Cyanokit,Cytacon,Methycobal

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 598   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, SC, intranasal,
Reference :-   Book : Martindale    Page : 2143   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pernicious anaemia IM 250 1000 micrograms Injection Dose: In patients without neurological involvement: Given on alternate days for 1 to 2 weeks, then 250 micrograms weekly until the blood count returns to normal. Maintenance doses of 1000 micrograms of hydroxocobalamin are given every 2 to 3 months.
2 Pernicious anaemia IM 1000 micrograms Injection Dose: If there is neurological involvement: given on alternate days and continued for as long as improvement occurs. Maintenance dose of 1000 micrograms are given every 2 months as hydroxocobalamin.
3 Pernicious anaemia IM 1000 micrograms Injection Dose: Prophylaxis of anaemia; associated with vitamin B12 deficiency resulting from gastrectomy or malabsorption syndromes: Given every 2 to 3 months.
4 Tobacco amblyopia IM 1000 micrograms Injection Dose: Given daily, followed by 1000 micrograms twice weekly for as long as improvement occurs. Thereafter, 1000 micrograms is given every 1 to 3 months.
5 Leber's optic atrophy IM 1000 micrograms Injection Dose: Given daily, followed by 1000 micrograms twice weekly for as long as improvement occurs. Thereafter, 1000 micrograms is given every 1 to 3 months.

Ref :-  Book : Martindale    Page : 2143   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antidote for cyanide poisoning IV infusion 70 mg/kg Injection
2 Amino acid metabolic disorders IM 1 mg Injection
3 Amino acid metabolic disorders 1 Month 1 mg QWK
4 Amino acid metabolic disorders 1 Month 1 mg bis in 7 d.
5 Cogenital transcobalamin II deficiency IM 1 mg Injection t.i.w.
6 Cogenital transcobalamin II deficiency 18 Year IM 1 mg Injection t.i.w.

Ref :- Book : Martindale    Page : 2144   Edition : 37,
►  Side Effect : rash, Itching, anaphylaxis, arrhythmia, gastrointestinal disturbance, fever, chills, hot flushing, Dizziness, malaise, acneform, bullous eruptions, tremor, headache, paraesthesia, chromaturia, allergic reactions, hypersensitivity reactions, injection site reactions including pain, erythemia, pruritus, induration, swelling, necrosis,
Ref :-   Book : Martindale    Page : 2142   Edition : 37,

►  Drug Interaction : Drug interaction of Hydroxycobalamin is with , , Oral Contraceptive,  Neomycin , Omeprazole , Colchicine ,
Ref :-   Book : Martindale    Page : 2143   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Absorption of vitamin B12 from the gastrointestinal tract may be reduced by neomycin, aminosalicylic acid, histamine H2-antagonists, omeprazole, and colchicine. Serum concentrations may be decreased by use of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations. Parenteral chloramphenicol may attenuate the effect of vitamin B12 in anaemia. ,
Ref :-   Book : Martindale    Page : 2143   Edition : 37,


►  Contraindication : Patients with suspected vitamin B12 deficiency without first confirming the diagnosis,
Ref :-   Book : Martindale    Page : 2142   Edition : 37,
  ►  Mechanism of Action :   Vitamin B12, a water-soluble vitamin, occurs in the body mainly as methylcobalamin (mecobalamin) and as adenosylcobalamin (cobamamide) and hydroxocobalamin. Mecobalamin and cobamamide act as coenzymes in nucleic acid synthesis. ,
Ref :-   Book : Martindale    Page : 2143   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Meat with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vitamin B12 --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )

  •   ►  URL -- https://books.google.co.in/books?id=biFBAAAAYAAJ&q=Gopalan, +C., +Rama+Sastri, +B., +%26+Balasubramanian, +S.+(1971).+Nutritive+value+of+Indian+foods.+Hyderabad, +India:+National+Institute+of+Nutrition, +Indian+Council+of+Medical+R,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 2143   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 2143   Edition : 37,