Hydroxyprogesterone Caproate is a Medicine belongs to sex hormone group whose information about Brand can be referenced from   Book : Martindale    Page : 2318   Edition : 37  

  ►   Brandname : Progesteron-Depot, Proluton Depot, Maintane, NT-Natal, Hylutin
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2318   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM
Reference :-   Book : Martindale    Page : 2317   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Recurrent miscarriage associated with proven progesterone deficiency IM 250 500 mg Injection QWK Dose: Given during the first half of pregnancy

Ref :-  Book : Martindale    Page : 2317   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Gastrointestinal disturbances, Change in appetite or weight, Fluid retention, Oedema, Acne, Chloasma (melasma), Allergic skin rashes, Urticaria, Mental depression, Breast changes including discomfort or occasionally gynaecomastia, Changes in libido, Hair loss, Hirsutism, Fatigue, Drowsiness, Insomnia, Fever, Headache, Premenstrual syndrome-like symptoms, Altered menstrual cycles, Irregular menstrual bleeding, Alterations in liver function tests , Jaundice
Ref :-   Book : Martindale    Page : 2317,2333   Edition : 37.  

►  Drug Interaction : Drug interaction of Hydroxyprogesterone Caproate is with ,  Carbamazapine , Griseofulvin , Phenobarbital , Phenytoin , Rifampicin , Aminoglutethimide
Ref :-   Book : Martindale    Page : 2317,2333   Edition : 37.   Martindale    Page : 2333   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Enzyme-inducing drugs such as carbamazepine, griseofulvin, phenobarbital, phenytoin, and rifampicin may enhance the clearance of Hydroxyprogesterone Caproate. These interactions are likely to reduce the efficacy of Hydroxyprogesterone Caproate -only contraceptives, and additional or alternative contraceptive measures are recommended. Aminoglutethimide markedly reduces the plasma concentrations of Hydroxyprogesterone Caproate, possibly through a hepatic enzyme-inducing effect; an increase in hydroxyprogesterone Caproate dose is likely to be required. Since hydroxyprogesterone Caproate can influence diabetic control an adjustment in antidiabetic dosage could be required. Hydroxyprogesterone Caproate may inhibit ciclosporin metabolism leading to increased plasma ciclosporin concentrations and a risk of toxicity.
Ref :-   Book : Martindale    Page : 2317,2333   Edition : 37.  

►  Contraindication : Hypertension, Renal impairment, Asthma, Epilepsy, Migraine, Cardiac impairment, Other conditions which may be aggravated by fluid retention, Undiagnosed vaginal bleeding, History or current high risk of arterial disease, Hepatic impairment, Breast or genital- tract carcinoma
Ref :-   Book : Martindale    Page : 2317,2333   Edition : 37.  
  ►  Mechanism of Action :   The progesterone-receptor complex forms adimer before binding to DNA. Like the estrogen receptor, it can form heterodimers as well as homodimers between to isomers, A and B. These isoforms are produced by alternative splicing of the same gene.
Ref :-   Book : Basic & Clinical pharmacology    Page : 723   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA