Hyoscine is a Medicine belongs to anticholinergic group whose information about Brand can be referenced from   Book : Martindale    Page : 1887   Edition : 37,

  ►   Brandname : Buscopan,Hyospan,Joy-Rides,Kwells,Scopoderm TTS,Pamine,Scopace,Transderm Scop,Setacol, Travacalm HO, Boro-Scopol, BS Carino

  ►  Strength : Tablet with 0.4  mg, Injection with 0.2  mg/ml, Cream with 3  %, Eye Drops with   , Ophthalmic Ointment with   , Ophthalmic Solution with   , Injection with 0.4  mg/ml, Transdermal Patch with 1.5  mg/2.5 cm2, Injection with 1  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12, Martindale    Page : 1886-1887   Edition : 37, Martindale    Page : 1886   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, SC, Transdermal, Topical,
Reference :-   Book : Martindale    Page : 1886   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperhidrosis Topical 3 % Cream
2 Motion sickness Oral 300 micrograms Tablet Dose: Taken 30 minutes before a journey, followed by 300 micrograms every 6 hours if required up to a maximum of 3 doses in 24 hours.
3 Antiemetic SC 200 micrograms 1 mg Injection
4 Antiemetic IV 200 micrograms 1 mg Injection
5 Antiemetic IM 200 micrograms 1 mg Injection
6 Smooth muscle spasm Oral 20 mg Tablet q.i.d.
7 Motion sickness Transdermal 1 mg Transdermal Patch Dose: transdermal patch which is placed behind the ear over 3 days. It should be applied 5 to 6 hours before travelling or on the preceding evening and removed at the end of the journey.

Ref :-  Book : Martindale    Page : 1886   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Motion sickness 4 Year 10 Year Oral 75 150 micrograms Tablet
2 Motion sickness 10Year Oral 150 300 micrograms Tablet
3 Motion sickness 3 Year 4 Year Oral 75 micrograms Tablet
4 Motion sickness 10Year Transdermal 1 mg Transdermal Patch
5 Smooth muscle spasm 6 Year 12 Year Oral 10 mg Tablet t.i.d.

Ref :- Book : Martindale    Page : 1886   Edition : 37,
►  Side Effect : Alteration in heart rate, Drug induced psychosis, Drug induced psychosis, Somnolence, Xerostomia, Blurred Vision, Dryness of the mouth with difficulty in swallowing and talking, thirst, reduced bronchial secretions, mydriasis, cycloplegia, photophobia, flushing of the face, dryness of the skin, Transient bradycardia followed by tachycardia, with palpitations and arrhythmias, difficulty in micturition, Reduction in the tone and motility of the gastrointestinal tract leading to constipation, drowsiness, fatigue, excitement, Restlessness, hallucinations, delirium,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 130   Edition : 3, Martindale    Page : 130   Edition : 3, Martindale    Page : 1343,1885   Edition : 37,

►  Drug Interaction : Drug interaction of Hyoscine is with CNS depressants, Alcohol, Monoamine Oxidase Inhibitor, Tricyclic antidepressant , Phenothiazine antipsychotics, ,  Metoclopramide , Domperidone , Cisapride , Amantadine ,
Ref :-   Book : Martindale    Page : 1343-1344,1886   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The effects of atropine and other antimuscarinics may be enhanced by use with other drugs having antimuscarinic properties, such as amantadine, some antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. The reduction in gastric motility caused by antimuscarinics may affect the absorption of other drugs. Antimuscarinics may also antagonise the gastrointestinal effects of cisapride, domperidone, and metoclopramide. Antimuscarinics and parasympathomimetics may counteract each others effects. The sedative effect of hyoscine may be enhanced by alcohol or other CNS depressants.,
Ref :-   Book : Martindale    Page : 1343-1344,1886   Edition : 37,


►  Contraindication : Patients who experience drowsiness should not drive or operate machinery, prostatic enlargement, paralytic ileus, pyloric stenosis, diarrhoea, narrow-angle glaucoma, infants aged less than 3 months, It should not be given to patients with myasthenia gravis except to reduce adverse muscarinic effects of an anticholinesterase,
Ref :-   Book : Martindale    Page : 1343,1885   Edition : 37,
  ►  Mechanism of Action :   Hyoscine is a tertiary amine antimuscarinic with central and peripheral actions. Antimuscarinic drugs are competitive inhibitors of the actions of acetylcholine at the muscarinic receptors of autonomic effector sites innervated by parasympathetic (cholinergic postganglionic) nerves; they are also inhibitors of the action of acetylcholine on smooth muscle lacking cholinergic innervation,
Ref :-   Book : Martindale    Page : 1344,1886   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Peppermint oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antispasmodic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1886   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA