Ibuprofen is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 70   Edition : 38,

  ►   Brandname : Brufen,Advil,Anadar,Ibu-Tab; Motrin; Inflapen; Mybu; Myofen

  ►  Strength : Chewable tablets with 50, 100  mg, Capsule with 200  mg, Suspension with 100/2.5  mg/ml, Suspension with 100/5  mg/ml, Tablet with 100  mg, Tablet with 200  mg, Tablet with 400  mg, Tablet with 600  mg, Tablet with 800  mg, drops with 40  mg/ml, Gel with 10  %, Cream with 5  %, Foam with 5  %, Spray with 5  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12, Martindale    Page : 68   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV infusion,
Reference :-   Book : Martindale    Page : 68   Edition : 38, Martindale    Page : 69   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Ductus arteriosus Oral 1.2 1.8 gm Daily in divided doses.
2 Fever Oral 200 400 mg Every 4 to 6 hours to a maximum of 1.2 g daily.
3 Ulcer and superficial wound Topical 500 micrograms/cm2 5% cream, foam, gel, or spray solution; a 10% gel used topically as a dressing.
4 Moderate-severe pain IV infusion 400 800 mg Injection q.i.d. It is also used for reduction of fever.

Ref :-  Book : Martindale    Page : 68   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Pain, inflammation of soft-tissue injuries, or fever 1 Month 3 Month Oral 5 mg/kg t.i.d/q.i.d
2 Pain, inflammation of soft-tissue injuries, or fever 3 Month 6 Month Oral 50 mg t.i.d.
3 Pain, inflammation of soft-tissue injuries, or fever 6 Month 12 Month Oral 50 mg t.i.d/q.i.d
4 Pain, inflammation of soft-tissue injuries, or fever 1 Year 4 Year Oral 100 mg t.i.d.
5 Pain, inflammation of soft-tissue injuries, or fever 4 Year 7 Year Oral 150 mg t.i.d.
6 Pain, inflammation of soft-tissue injuries, or fever 7 Year 10 Year Oral 200 mg t.i.d.
7 Pain, inflammation of soft-tissue injuries, or fever 10 Year 12 Year Oral 300 mg t.i.d.
8 Pain, inflammation of soft-tissue injuries, or fever 12 Year 18 Year Oral 300 400 mg t.i.d/q.i.d
9 Severe symptoms 3 Month 12 Year Oral 30 mg/kg
10 Fever 6 months and over Oral 5 10 mg/kg
11 Rheumatic disease including juvenile idiopathic arthritis 3 months and over Oral 10 mg/kg t.i.d/q.i.d
12 Post-immunisation pyrexia Oral 50 mg
13 Pain 6 months and over Oral 10 mg/kg t.i.d/q.i.d

Ref :- Book : Martindale    Page : 68   Edition : 38, Martindale    Page : 69   Edition : 38,
Precaution :- If a Patient is using 'Ibuprofen' drug in  acute kidney injury   disease, then Please be avoided .

Precaution :- If a Patient is using 'Ibuprofen' drug in  bronchial asthma  disease, then Please induces bronchospasm .

Precaution :- If a Patient is using 'Ibuprofen' drug in ascitis disease, then Please CAN LEAD TO DEVELOPMENT OF ARF,diuretic resistance   if he ever suffered from CIRRHOSIS disease.
Precaution :- If a Patient is using 'Ibuprofen' drug in  esophagitis  disease, then Please aggrevates reflux .

Precaution :- If a Patient is using 'Ibuprofen' drug in  autoimmune hemolytic anemia  disease, then Please Avoid .

►  Side Effect : intraventricular haemorrhage, periventricular leucomalacia, bronchopulmonary dysplasia, pulmonary haemorrhage, necrotising enterocolitis, intestinal perforation, oliguria, fluid retention, haematuria, hypoxaemia, gastrointestinal haemorrhage,
Ref :-   Book : Martindale    Page : 69   Edition : 38,

►  Drug Interaction : Drug interaction of Ibuprofen is with Bisphosphonates, Alcohol, selective serotonin reuptake inhibitors, Corticosteroid , sulfonylurea antidiabetic , Beta Blockers , Potassium -Sparing Diuretics , Diuretics, Angiotensin-conveting Enzyme Inhibitors , Cardiac Glycosides, ,  Mifepristone , Ritonavir, Pentoxifylline , Sibutramine, Erlotinib, Iloprost , Ticlopidine , Clopidogrel , Venlafaxine , Phenytoin , Tacrolimus , Cyclosporine , Methotrexate, Phenylbutazone, Azapropazone,
Ref :-   Book : Martindale    Page : 70,107   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Interactions involving Ibuprofen include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassiumsparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. Ibuprofen may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with Ibuprofen is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. Ritonavir may increase the plasma concentrations of Ibuprofen. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by Ibuprofen or aspirin may alter the efficacy of mifepristone.,
Ref :-   Book : Martindale    Page : 70,107   Edition : 38,


►  Contraindication : Ibuprofen injection should not be given to neonates with life-threatening infection, with significant renal impairment, or with known or suspected necrotising enterocolitis., Infants who are bleeding (especially gastrointestinal bleeding or intracranial haemorrhage) or who have thrombocytopenia or coagulation defects should also not be given parenteral ibuprofen, and those given it should be monitored during treatment for signs of bleeding.,
Ref :-   Book : Martindale    Page : 69   Edition : 38,
  ►  Mechanism of Action :   Inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Mulathi with Another pathway, Mulathi with Another pathway,

  ►  Pathway with its reference as follows :-
  • Analgesic --- (Duck, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). America: CRC. )
  • Narcotine have Analgesic effect --- (: Duke, J. & Duke, J. (2002). Handbook of medicinal herbs. Boca Raton, FL: CRC Press. )

  •   ►  URL -- https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PA822&dq=Hand+Book+Of+Medicinal+Herbs+(2nd+ed.)&hl=en&sa=X&redir_esc=y#v=onepage&q=Hand%20Book%20Of%20Medicinal%20Herbs%20(2nd%20ed.)&f=false, https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PA822&dq=:+Duke, +J.+%26+Duke, +J.+.+Handbook+of+medicinal+herbs.+Boca+Raton&hl=en&sa=X&redir_esc=y#v=onepage&q=%3A%20Duke%2C%20J.%20%26%,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- COLEUS FORSKOHLII I.E. MAKANDI with Used with caution by patients on asthma or blood pressure medication because it intensify the effect of drug .t , BETANIN HCL with Increase the risk of stomach bleeding, LITHIUM with Most NASDs inhibit the exretion of lithium from the body , resulting in higher blood levels of the mineral , though sulindac ., CANNABIS with Cannabis antagonist the effect of NSAIDs,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 70   Edition : 38,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 70   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 70   Edition : 38,