Ibutilide Fumarate is a Medicine belongs to class iii antiarrhythmics group whose information about Brand can be referenced from   Book : Martindale    Page : 1407   Edition : 38,

  ►   Brandname : Corvert

  ►  Strength : Injection with 0.1  gm/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 249   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion,
Reference :-   Book : Martindale    Page : 1407   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Atrial flutter IV 1 mg Injection Single dose, in patients weighing 60 kg and over.
2 Atrial fibrillation IV 1 mg Injection Single dose, in patients weighing 60 kg and over.
3 Atrial fibrillation IV 10 micrograms/kg Injection Given as a single dose, in patients weighing less than 60 kg, infused over 10 minutes.
4 Atrial flutter IV 10 micrograms/kg Injection Given as a single dose, in patients weighing less than 60 kg, infused over 10 minutes.

Ref :-  Book : Martindale    Page : 1407   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Ibutilide Fumarate' drug in  atrial flutter  disease, then Please contraindicated in heart block .

►  Side Effect : heart block, hypertension, hypotension, bradycardia, prolong QT interval , arrhythmia, torsade de pointes, nausea, vomiting,
Ref :-   Book : Martindale    Page : 1443   Edition : 37,

►  Drug Interaction : Drug interaction of Ibutilide Fumarate is with NA

  ►    Mechanism of Drug Drug Interaction :  Use of ibutilide with other antiarrhythmics or drugs that prolong the QT interval should be avoided. For the synergistic effect of magnesium and ibutilide in producing cardioversion. ,
Ref :-   Book : Martindale    Page : 1407   Edition : 38,


►  Contraindication : should be stopped if the QT interval becomes markedly prolonged,
Ref :-   Book : Martindale    Page : 1407   Edition : 38,
  ►  Mechanism of Action :   Block K+ channels, resulting in longer action potential plateau and prolonged repolarization,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 420   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Faecal, Renal, Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1407   Edition : 38,


►    Plasma Half-life :
  Min value :-   2 ,    Max value :-   12 hours,
Ref :-   Book : Martindale    Page : 1407   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA