Ifosfamide is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 807   Edition : 38,

  ►   Brandname : Ifex; Holoxan; Ifocip

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 807   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 807   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Solid tumours IV 8 12 gm/m2 Injection Including those of the cervix, lung, ovary, testis, and thymus, as well as in sarcoma and in the treatment of lymphomas. divided over 3 to 5 days, The course repeated at 2 to 4 week intervals. Ifosfamide should be given with mesna and adequate hydration should be maintained, to avoid urological toxicity; fluid intake should not be less than 2 litres daily.

Ref :-  Book : Martindale    Page : 806   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Confusion, drowsiness, depressive psychosis, hallucinations, , Myelosuppression, thrombocytopenia, anaemia, haemorrhagic cystitis, Alopecia occurs in about 20% of patients given low doses and in practically all patients given high doses., Hyperpigmentation of skin, especially that of the palms and soles, and of the nails, nausea, vomiting, Inappropriate secretion of antidiuretic hormone,
Ref :-   Book : Martindale    Page : 806   Edition : 38, Martindale    Page : 806,772   Edition : 38,

►  Drug Interaction : Drug interaction of Ifosfamide is with Live Vaccines, Anticoagulant ,  Cisplatin ,
Ref :-   Book : Martindale    Page : 807,733   Edition : 38, Martindale    Page : 807   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Ifosfamide Enhancement of cisplatin-induced ototoxicity and nephrotoxicity. Ifosfamide produced an increased anticoagulant effect Ifosfamide that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalized infection with live vaccines. ,
Ref :-   Book : Martindale    Page : 807,1532,768,733   Edition : 38,


►  Contraindication : Severe bone marrow depression,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 696   Edition : 3,
  ►  Mechanism of Action :   Covalently bind DNA, often cross-link to DNA or associated proteins. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 696   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 807   Edition : 38,


►    Plasma Half-life :
  Min value :-   15 hours(reported after a single high-dose intravenous bolus) 4 to 8 hours(at lower doses),    Max value :-   NA
Ref :-   Book : Martindale    Page : 807   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA