Iloprost is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1409   Edition : 38,

  ►   Brandname : Ventavis

  ►  Strength : Inhalant with 10  microgram/ml, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12, Martindale    Page : 1408   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, inhalation,
Reference :-   Book : Martindale    Page : 1408   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Peripheral vascular disease IV infusion 0.5 nanograms/kg per minute 2 nanograms/kg per minute Injection q.i.d. The course of treatment may be up to 4 weeks.
2 Pulmonary hypertension IV infusion 1 nanograms/kg per minute 8 nanograms/kg per minute Injection q.i.d.
3 Pulmonary hypertension inhalation 2.5 or 5 micrograms nebulized solution Inhaled 6 to 9 times daily.

Ref :-  Book : Martindale    Page : 1408   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Pulmonary hypertension 8 Year over 8 Year inhalation 1 8 nanograms/kg per minute nebulized solution q.i.d.
2 Raynaud’s syndrome 12 Year over 12 Year IV infusion 1 8 nanograms/kg per minute Injection q.i.d.

Ref :- Book : Martindale    Page : 1408   Edition : 38,
►  Side Effect : Cough, hypotension, flushing, headache, sweating, nausea, vomiting, abdominal discomfort, diarrhoea, anxiety, Nervousness, flu-like symptoms, Hyperglycaemia, drowsiness, chest pain, increased heart rate, Bradycardia with pallor,, Erythema over the intravenous infusion site, jaw pain or nonspecific musculoskeletal pain,,
Ref :-   Book : Martindale    Page : 1408   Edition : 38, Martindale    Page : 1408,1376   Edition : 38,

►  Drug Interaction : Drug interaction of Iloprost is with Antiplatelet drugs, Antihypertensive Agents , VASODILATORS ,  NA

  ►    Mechanism of Drug Drug Interaction :  Iloprost may increase the effect of other vasodilators and antihypertensives. The use of iloprost with other inhibitors of platelet aggregation may increase the risk of bleeding.,
Ref :-   Book : Martindale    Page : 1408   Edition : 38,


►  Contraindication : Risk of bleeding, congestive heart failure due to severe left ventricular systolic dysfunction,
Ref :-   Book : Martindale    Page : 1408,1376   Edition : 38,
  ►  Mechanism of Action :   Iloprost, a vasodilator and platelet aggregation inhibitor, is a stable analogue of the prostaglandin epoprostenol ,
Ref :-   Book : Martindale    Page : 1408   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Renal,
Ref :-   Book : Martindale    Page : 1409   Edition : 38,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA