Imipenem is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 311   Edition : 38  

  ►   Brandname : Cilanem, Primaxin, Cilaspene, Cimispect
  ►  Strength : Injection with 250 mg/vial.  Injection with 500 mg/vial.  Injection with 750 mg/vial.  Injectable Suspension with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12   Martindale    Page : 311   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, IM
Reference :-   Book : Martindale    Page : 309   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderate infections IM 500 mg or 750 mg Injection b.d.
2 Antibacterial IV infusion 250 mg or 500 mg Injection Infused over 20 to 30 minutes.
3 Antibacterial IV infusion 750 mg or 1gm Injection Over 40 to 60 minutes.

Ref :-  Book : Martindale    Page : 309   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infections caused by susceptible gram-positive and gram-negative bacteria IV infusion 500 mg Injection
2 Infections caused by susceptible gram-positive and gram-negative bacteria Neonate under 7 days IV infusion 20 mg/kg Injection b.d.
3 Infections caused by susceptible gram-positive and gram-negative bacteria 7 Day 21 Day IV infusion 20 mg/kg Injection t.i.d.
4 Infections caused by susceptible gram-positive and gram-negative bacteria 21 Day 28 Day IV infusion 20 mg/kg Injection q.i.d.
5 Infections caused by susceptible gram-positive and gram-negative bacteria 1 Month 3 Month IV infusion 20 mg/kg Injection q.i.d.
6 Infections caused by susceptible gram-positive and gram-negative bacteria 3 Months over 3 Months IV infusion 15 mg/kg Injection q.i.d.
7 Cystic fibrosis 1 Month IV infusion 25 mg/kg Injection q.i.d.
8 Life-threatening infections IV infusion 25 mg/kg (to a maximum dose of 1 gm) Injection q.i.d.

Ref :- Book : Martindale    Page : 309   Edition : 38   Martindale    Page : 310   Edition : 38  
►  Side Effect : Nausea, Vomiting, Diarrhea, Tooth or tongue discoloration, Altered taste, Pseudomembranous colitis, Increase in liver enzymes, Anaphylaxis, Abnormalities in haematological parameters, , Seizure, Nephrotoxicity, Harmless reddish coloration of urine, Local reactions such as pain or thrombophlebitis
Ref :-   Book : Martindale    Page : 310   Edition : 38.  

►  Drug Interaction : Drug interaction of Imipenem is with Ganciclovir
Ref :-   Book : Martindale    Page : 310   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Seizures have been reported in patients given ganciclovir with imipenem-cilastatin
Ref :-   Book : Martindale    Page : 310   Edition : 38.  


►  Contraindication : Renal impairment, Hypersensitive to it and should be given with caution to patients known to be hypersensitive to penicillins, cephalosporins, or other beta lactams.
Ref :-   Book : Martindale    Page : 310   Edition : 38.  
  ►  Mechanism of Action :   Prevents bacterial cell wall synthesis by binding to and inhibiting cell wall transpeptidases.
Ref :-   Book : Basic & Clinical pharmacology    Page : 806   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal
    Ref :-   Book : Martindale    Page : 311   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 310   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours(I.M), 20 to 30 minutes(I.V infusion),    Max value :-   NA
    Ref :-   Book : Martindale    Page : 310   Edition : 38.