Imipenem is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 311   Edition : 38,

  ►   Brandname : Cilanem,Primaxin,Cilaspene, Cimispect

  ►  Strength : Injection with 250  mg/vial, Injection with 500  mg/vial, Injection with 750   mg/vial, Injectable Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12, Martindale    Page : 311   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, IM,
Reference :-   Book : Martindale    Page : 309   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderate infections IM 500 mg or 750 mg Injection b.d.
2 Antibacterial IV infusion 250 mg or 500 mg Injection Infused over 20 to 30 minutes.
3 Antibacterial IV infusion 750 mg or 1gm Injection Over 40 to 60 minutes.

Ref :-  Book : Martindale    Page : 309   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infections caused by susceptible gram-positive and gram-negative bacteria IV infusion 500 mg Injection
2 Infections caused by susceptible gram-positive and gram-negative bacteria Neonate under 7 days IV infusion 20 mg/kg Injection b.d.
3 Infections caused by susceptible gram-positive and gram-negative bacteria 7 Day 21 Day IV infusion 20 mg/kg Injection t.i.d.
4 Infections caused by susceptible gram-positive and gram-negative bacteria 21 Day 28 Day IV infusion 20 mg/kg Injection q.i.d.
5 Infections caused by susceptible gram-positive and gram-negative bacteria 1 Month 3 Month IV infusion 20 mg/kg Injection q.i.d.
6 Infections caused by susceptible gram-positive and gram-negative bacteria 3 Months over 3 Months IV infusion 15 mg/kg Injection q.i.d.
7 Cystic fibrosis 1 Month IV infusion 25 mg/kg Injection q.i.d.
8 Life-threatening infections IV infusion 25 mg/kg (to a maximum dose of 1 gm) Injection q.i.d.

Ref :- Book : Martindale    Page : 309   Edition : 38, Martindale    Page : 310   Edition : 38,
►  Side Effect : nausea, vomiting, diarrhea, Tooth or tongue discoloration, altered taste, Pseudomembranous colitis, increase in liver enzymes, anaphylaxis, abnormalities in haematological parameters, , seizure, nephrotoxicity, harmless reddish coloration of urine, Local reactions such as pain or thrombophlebitis,
Ref :-   Book : Martindale    Page : 310   Edition : 38,

►  Drug Interaction : Drug interaction of Imipenem is with Ganciclovir ,
Ref :-   Book : Martindale    Page : 310   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Seizures have been reported in patients given ganciclovir with imipenem-cilastatin,
Ref :-   Book : Martindale    Page : 310   Edition : 38,


►  Contraindication : renal impairment, Hypersensitive to it and should be given with caution to patients known to be hypersensitive to penicillins, cephalosporins, or other beta lactams.,
Ref :-   Book : Martindale    Page : 310   Edition : 38,
  ►  Mechanism of Action :   Prevents bacterial cell wall synthesis by binding to and inhibiting cell wall transpeptidases.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 806   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 311   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 310   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2 hours(I.M), 20 to 30 minutes(I.V infusion),    Max value :-   NA
    Ref :-   Book : Martindale    Page : 310   Edition : 38,