Imipenem and Cilastatin is a Medicine belongs to Beta-lactam antibacterial group whose information about Brand can be referenced from   Book : Martindale    Page : 311   Edition : 38,

  ►   Brandname : Cilanem,Imi-Cila,Primaxin

  ►  Strength : Injection with 250  mg, Injection with 500  mg, Injection with 750  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 309   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severity of the infection IV 1 2 gm Injection Daily 6 or 8 hourly in divided doses.
2 Life-threatening infections IV 50 mg/kg Injection Daily.
3 Mild to moderate infections IM 500 mg Injection b.d.
4 Mild to moderate infections IM 750 mg Injection b.d.
5 Endovascular infections including endocarditis IV 500 mg Injection q.i.d.
6 IV 500 mg Injection q.i.d. Pseudomonas aeruginosa and Related Species.
7 Melioidosis 500 mg q.i.d. For 2 weeks + TMP-SMX.
8 Glanders 500 mg q.i.d. For 2 weeks + TMP-SMX.
9 Community acquired pneumonia IV 500 mg Injection q.i.d. With ciprofloxacin.
10 Severe Sepsis 0.5 gm q.i.d.
11 Secondary peritonitis IV 500 mg Injection q.i.d.
12 Campylobacter Infection IV 500 mg Injection q.i.d.
13 Wound Infections 500 mg q.i.d.

Ref :-  Book : Harrison's principles of internal medicine    Page : 1078, 1269, 1185, 1288, 2135, 2229.    Edition : 18, Harrison's principles of internal medicine    Page : 1078, 1269, 1185, 1288, 2135, 2229.    Edition : 18,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypersensitivity reactions, Skin rashes, Urticaria, eosinophilia, fever, gastrointestinal effects, nausea, vomiting, diarrhea, Tooth or tongue discoloration, altered taste, Superinfection with non-susceptible organisms, Pseudomembranous colitis, increase in liver enzymes, abnormalities in haematological parameters, Pain, thrombophlebitis, seizure, convulsion, reddish coloration of urine, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis,
Ref :-   Book : Martindale    Page : 310   Edition : 38,

►  Drug Interaction : Drug interaction of Imipenem and Cilastatin is with Ganciclovir , Mycophenolate mofetil ,
Ref :-   Book : Martindale    Page : 310   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Seizures have been reported in patients given ganciclovir with imipenem-cilastatin. Decreased plasma-valproate concentrations (sometimes with loss of seizure control) attributed to imipenem.,
Ref :-   Book : Martindale    Page : 310   Edition : 38,


►  Contraindication : NA
  ►  Mechanism of Action :   Imipenem, like other -lactam antibiotics, binds to penicillin-binding proteins, disrupts bacterial cell wall synthesis, and causes death of susceptible microorganisms,
Ref :-   Book : Goodman    Page : 1500   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 312   Edition : 38,


►    Plasma Half-life :
  Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 312   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,