Imipenem and Cilastatin is a Medicine belongs to Beta-lactam antibacterial group whose information about Brand can be referenced from   Book : Martindale    Page : 311   Edition : 38  

  ►   Brandname : Cilanem, Imi-Cila, Primaxin
  ►  Strength : Injection with 250 mg.  Injection with 500 mg.  Injection with 750 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, IM
Reference :-   Book : Martindale    Page : 309   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 N.F.R.B

Ref :-  Book :    Page :    Edition :   



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 CYSTIC FIBROSIS and LUNG INFECTION IV 45 100 mg/kg/day Injection t.i.d/q.i.d

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1492   Edition : 19  
►  Side Effect : Hypersensitivity reactions, Skin rashes, Urticaria, Eosinophilia, Fever, Gastrointestinal effects, Nausea, Vomiting, Diarrhea, Tooth or tongue discoloration, Altered taste, Superinfection with non-susceptible organisms, Pseudomembranous colitis, Increase in liver enzymes, Abnormalities in haematological parameters, Pain, Thrombophlebitis, Seizure, Convulsion, Reddish coloration of urine, Erythema multiforme, Exfoliative dermatitis, Stevens-Johnson syndrome, Toxic epidermal necrolysis
Ref :-   Book : Martindale    Page : 310   Edition : 38.  

►  Drug Interaction : Drug interaction of Imipenem and Cilastatin is with Ganciclovir , Mycophenolate mofetil
Ref :-   Book : Martindale    Page : 310   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Seizures have been reported in patients given ganciclovir with imipenem-cilastatin. Decreased plasma-valproate concentrations (sometimes with loss of seizure control) attributed to imipenem.
Ref :-   Book : Martindale    Page : 310   Edition : 38.  


►  Contraindication : Hypersensitive to it, Caution to patients known to be hypersensitive to penicillins, cephalosporins, or other beta lactams, Renal impairment
Ref :-   Book : Martindale    Page : 310   Edition : 38.  
  ►  Mechanism of Action :   Imipenem, like other -lactam antibiotics, binds to penicillin-binding proteins, disrupts bacterial cell wall synthesis, and causes death of susceptible microorganisms
Ref :-   Book : Goodman    Page : 1500   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 312   Edition : 38.  

►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 312   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .