Imipramine is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 427   Edition : 38,

  ►   Brandname : Tofranil,Antidep,Depsonil; Depik

  ►  Strength : Tablet with 10  mg, Tablet with 25  mg, Tablet with 50  mg, Capsule with 75  mg, Capsule with 100  mg, Capsule with 125  mg, Capsule with 150  mg, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12, Martindale    Page : 426   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 426   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral up to 75 mg Tablet/Capsule In divided doses initially, gradually increased to 150 to 200 mg daily as necessary; higher doses of up to 300 mg daily may be required in severely depressed patients.
2 Depression Oral 25mg 50 mg Tablet/Capsule Daily, for initial therapy in the elderly and adolescents, increasing to a maximum of 100 mg daily as required.

Ref :-  Book : Martindale    Page : 426   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Nocturnal enuresis 6 Year 7 Year 20 to 25 kg Oral 25 mg Tablet/Capsule
2 Nocturnal enuresis 8 Year 11 Year 25 to 35 kg Oral 25 50 mg Tablet/Capsule
3 Nocturnal enuresis over than 11 Year 35 to 54 kg Oral 50 75 mg Tablet/Capsule

Ref :- Book : Martindale    Page : 426   Edition : 38,
►  Side Effect : heart block, cardiac arrhythmia, Orthostatic hypotension, myocardial infarction, agranulocytosis, jaundice, seizure, bloating, constipation, Xerostomia, Dizziness, Somnolence, urinary retention, Worsening depression with suicidal thoughts,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 221   Edition : 3,

►  Drug Interaction : Drug interaction of Imipramine is with Antipsychotics, Calcium Channel Blockers , some antiepileptics , Barbiturates , Alcohol, Antimuscarinic, ,  Methylphenidate , Cimetidine , Rifampicin ,
Ref :-   Book : Martindale    Page : 426,406   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit or induce the cytochrome P450 isoenzyme CYP2D6 may affect Imipramine metabolism and produce marked alterations in plasma concentrations. Adverse effects may be enhanced by antimuscarinic drugs or CNS depressants, including alcohol. Barbiturates and other enzyme inducers such as rifampicin and some antiepileptics can increase the metabolism of Imipramine and may lower plasma concentrations and reduce antidepressant response. Cimetidine, methylphenidate, antipsychotics, and calciumchannel blockers can reduce the metabolism of the Imipramine , leading to the possibility of increased plasma concentrations and accompanying toxicity. ,
Ref :-   Book : Martindale    Page : 426,406   Edition : 38,


►  Contraindication : concomitant use of MAO inhibitor, Cardiac conduction system defects, use in patients during acute recovery after a myocardial infraction,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 221   Edition : 38,
  ►  Mechanism of Action :   Inhibit reuptake of 5-HT and NE from the synaptic cleft by respectively blocking 5-HT and NE reuptake transporters, and thereby cause enhancement of postsynaptic responses.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 221   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Califormia with ,

  ►  Pathway with its reference as follows :-
  • Isoquinoline Alkaloids i.e. Californidine have antidepressent effect --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- https://books.google.co.in/books?id=KwYIsLRyDp4C&pg=SL1-PA47&dq=Kokate, +C.K.+Pharmaco,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 427   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   9 ,    Max value :-   28 hours,
    Ref :-   Book : Martindale    Page : 427   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA